Hi @donnacsec At 45, your daughter is so young to be experiencing strokes. I’m sure this is elevating anxiety levels for the both of you!
From my understanding, an elevated D-dimer can be an indication of blood clotting condition, but not a confirmation of one. So usually there are follow-up tests to find the underlying cause.
Factor V Leiden is a mutation of one of the clotting factors in the blood. This mutation can increase the chance of developing abnormal blood clots, which your daughter has already experienced. Medications to prevent clotting are recommended such as low dose aspirin.
I know you’d like to learn as much as possible about your daughter’s condition. To get you started I’m posting some links below with lots of informational material.

~From Mayo Clinic:
https://www.mayoclinic.org/diseases-conditions/factor-v-leiden/symptoms-causes/syc-20372423
~From Cleveland Clinic: https://my.clevelandclinic.org/health/diseases/17896-factor-v-leiden

~From Bloodclot.org:
https://bloodclot.org/factor-v-leiden/
There are some great discussions in Connect with other members who have Factor V Leiden. Here are links to a few of those conversations.
~Factor V Leiden-Deficiency blood clotting condition:
https://connect.mayoclinic.org/discussion/factor-v-leiden-deficiency-blood-clotting-condition/
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~Anyone with Factor V Leiden?
https://connect.mayoclinic.org/discussion/anyone-with-factor-v-leiden-mutation-mthfr-blood-disorder/
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~Anybody else have Factor V Leiden?
https://connect.mayoclinic.org/discussion/anybody-else-have-factor-2-and-factor-v-leiden/
Since this is an inherited condition do you recall anyone else in your family or husband’s family having blood clotting issues?