1. < Osteoporosis & Bone Health

Tymlos side effects I've encountered

Posted by anniesan @anniesan, Oct 2, 2022

Hi. I started Tymlos in February 2022 and about a month after starting it I began experiencing excruciating muscle spasms, esp in upper thighs and feet, neuropathy, as well as debilitating hip, leg, and back pain. My doctor wanted me to try and stay on it for at least a year, but I absolutely could not go on living with the pain I experienced. I stopped taking the Tymlos completely 6 days ago and all my symptoms have subsided. Has anyone else experienced these side effects while on Tymlos?

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njx58 | @njx58 | Apr 6 2:26pm
In reply to @grammyof7 "I know with my situation I was told I will need to go on another med..." + (show)
@grammyof7

I know with my situation I was told I will need to go on another med after my 2 years of tymlos. Ive been told that I'll need to protect the gains I'll make while on tymlos. That decision will be made about what drug I'll go on come the end of 2025.

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I am in a similar situation, with similar timing. It sounds like it will be Reclast or Fosamax. I am leaning toward the latter, but we'll see !

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tangydog | @tangydog | Apr 7 12:08pm

I have been on tymlos for 3 weeks and take at night as I take so many other items in the morning and wanted to sleep thru side effects. I have been reading and hearing and I found 1 article from NIH suggesting take tymlos in the morning prior to exercise as the exercise soon after will help build bone quicker? Isn't tymlos in your system 24hrs anyways? I am confused how to move forward? Any thoughts? I will speak to my Dr but guessing he will say it doesn't matter?

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njx58 | @njx58 | Apr 7 12:28pm
In reply to @tangydog "I have been on tymlos for 3 weeks and take at night as I take so..." + (show)
@tangydog

I have been on tymlos for 3 weeks and take at night as I take so many other items in the morning and wanted to sleep thru side effects. I have been reading and hearing and I found 1 article from NIH suggesting take tymlos in the morning prior to exercise as the exercise soon after will help build bone quicker? Isn't tymlos in your system 24hrs anyways? I am confused how to move forward? Any thoughts? I will speak to my Dr but guessing he will say it doesn't matter?

Jump to this post

The half-life of Tymlos is around an hour. It is not in your system 24 hours a day.

There was some evidence that taking Forteo in the morning had a slight advantage over evening, but I think that is secondary to taking it at a time that minimizes side effects. In other words, do what works best for you. The main thing is to take it.

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