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Osteoporosis meds: How do they work?

Osteoporosis & Bone Health | Last Active: Jan 2 11:41am | Replies (259)

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@jaleen

Posted by Jaleen:
Before you go on Prolia, I suggest that you log in on: "Center for Health Journalism" and click on "Prolia: Another wonder drug that wasn't".
I've spent countless hours studying Prolia and every time that I re-examined this medication, I came to the conclusion that, in spite of my severe osteoporosis (at -3.5), the risks of taking this drug far outweigh any promised benefits. I'm eating right, taking calcium and Vitamin D and K along with my regular meds, pole-walking and doing floor exercises. At 85, I feel great and see no reason to change what I am doing. To all persons in the Mayo Clinic chat room, I'd like to say - DO YOUR HOMEWORK ON THIS AND ANY OTHER MEDS THAT PROMISE TO STRENGTHEN YOUR BONES! I've read dozens of user reviews, and for every review that reported improved dexa-scan scores and no side effects, there are at least 5 others who reported that since taking this drug, their lives have been turned upside down with pain and other bad reactions and they warn others on the dangers of this drug! I am glad that, from the start, I decided to say "no" to Prolia or any other drug (such as Forteo) that purports to build bone density. For me, it was the right decision.

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Replies to "Posted by Jaleen: Before you go on Prolia, I suggest that you log in on: "Center..."

I’m wondering what Mayo Clinic’s take is on this? I was prescribed Fosamax and didn’t ask enough questions and had several adverse reactions with it so quit. Have appt. to discuss with Dr. he is suggesting Prolia, at age 69, are risks takening it worse than not?

Hello @madgee49. I am not a medical professional, nor do we give medical advice on Mayo Clinic, but I can help provide some resources from Mayo Clinic to help shed light on your question. Since we all tolerate medications so differently, it is hard to know exactly how a medication will work, but here are a few links that may help provide a bit more information:

- https://www.mayoclinic.org/diseases-conditions/osteoporosis/in-depth/osteoporosis-treatment/art-20046869
- https://www.mayoclinic.org/diseases-conditions/osteoporosis/expert-answers/osteoporosis-drug-risks/faq-20058121

I suggest that you log into User reviews - Prolia. There are other sites with reviews as well. I have a fat folder with nothing but reviews on Forteo and Prolia. I came to the conclusion, after spending hours on this, that it is like Russian roulette. I'm not a gambler so I said "no" even though my doctor said he thought the benefits outweigh the risks. I disagree. I think Forteo and Prolia should have had more testing before they were approved by the FDA. I read the reviews on the Freedom Trials, on which the FDA approval was based, and I was not convinced of their accuracy. ....One recent writer on Prolia wrote: Call FDA to report negative side effects 1 888-463-6332. Especially if you are having stomach issues. Be sure to report if the doctor reviewed your possible side effects or did they say "No side effects". Tell the FDA about your doctors reaction to your reports of Prolia side effects. Did they say this couldn't be prolia? The more we report the more likely they will review this drug. See Ask a patient anyone on prolia Topix any one on prolia. You are not alone.

Thank you for taking time for writing back. I really appreciate it very much! LIKE YOU I am not a gambler. I am still in this diet and supplement regimen and haven't gotten to decide if I am going for this Prolia injection treatment of choice. I am still in the mend from my broken vertebrae and still is in body brace. I have read a lot of bad reviews on Prolia and other drugs of choice for osteoporosis.
I am on the diet and long slow walks regimen as of now!!

It sounds to me as if you are doing all thel right thigs. I am curious - which vertebrae did you break and did you have it operated on?

Hi. Thank you for your experience on this. I have been told again and again that I need to take drugs for my -4.3 DEXA scan results. But after having experienced side effects, simply taking Boniva for osteopenia ( couldn’t walk for a week after just one pill) I am loathe to take foteo for two years then be stuck for the rest of my life taking prolia. Forteo doesn’t sound so bad from what I’m reading, however, I am currently not on any drugs at all at the age of 70. And I don’t want to and be stuck for the rest of my life on drugs with side effects. So can you tell me how you’re doing after all this time on your regimen?