I am 70F on HU x 7 years, and my experience is that it exacerbates a lot of the normal aging annoyances--hair loss, dry skin, digestive probs (constipation in my case), environmental sensitivities, etc. My oncologist concurred and recommended more fiber, a probiotic, and whatever otc's work to soothe hair/skin issues. I tend to be a "grit your teeth and ignore it" type person, but I am much more comfortable (and nicer!) if I pay a little more attention to what the old carcass is telling me.

I grow herbs to cook with. I have to say that rinsing my head with warm rosemary or sage tea sounds lovely, even if it doesn't keep my hair from falling out!

My dad had ET (died with it at 82) and noticed similar things, but much less was known about MPNs in those days, and hematologists were not very understanding.