MAC infection treatment

More on stem cell research. Sorry. I could not download and upload this but you can google the following: The research done in China was published in"Journal of Protein and Cell". Title is: "Regenerated functional alveoli by adult human SOX9? airway basal cell transplantation". Previous mice study with BE recovered lost respiratory function. 2 human patients showed continuous improvement. Maybe not "cured" but researchers did imply cure after 5 years. Also mentioned that the research team has already performed 80 stem cell transplants in patients with COPD. Interstitial lung disease, BE, and other lung diseases. That's very interesting!

That is interesting. I had to take the 3 antibiotics every day. I tested positive after 4 months of treatment then had to continue for a year after that. I was very ill before I started treatment in December 2022. I feel much better this time and was quite shocked to learn that the NTM was back. America is way ahead of the UK with its treatment. Thank you for your support. I need lots of prayers! We eat early too and my bedtime is 10pm. I do not want to be off work this time.

Hi there,
I live in London. I was on the b8g 3 for 14 months felt pretty awful but cleared Mac after 6 months. I was on daily treatment I had to stop working. So many side effects and my weight loss was crazy. I am a slim lady anyway but I was less than 8 stone. It has taken me a whole year to put some weight back on. Felt so relieved when I stopped treatment. I ended up having to have treatment for an irritated bladder . I found out this week that my MAC has returned.i have to go on tje big 3 again. I will do it but if I feel as awful as I did the last time I am not sure if I will last the course. I will take my meds in the evening with food and I will take probiotics every morning. My anti nausea was the only thing that stopped me fro. Getting sick. I only want to take the big 3 three times a week as I do not want to have to give up my new part time job. Anyone got any advice about taking these antibiotics. I worry about the serious side effects. I am a 58 year old female who has rarely been ill the wham your life changes utterly

This subject is one of great interest to those of us with lung diseases for which there is currently no known cure. The paper you cited ( https://pubmed.ncbi.nlm.nih.gov/29344809/ ) is from a study 7-8 years ago, so I dove into Google Scholar to see if there is any news of note.

Here is article from 2023:
https://link.springer.com/article/10.1186/s12967-023-04729-9
The current limitation is a familiar one - HOW to manufacture these unique stem cells in sufficient quantity and purity that they are a practical solution for thousands to millions of people. That breakthrough has not yet been achieved, so any treatments now will be in a research setting like in the study cited above, or as last-resort care for those who are at the end of life and for whom lung transplant is not as possibility.

This is part of their conclusion: " To date, most of the research on the treatment of chronic lung diseases with engineered MSC-exos has been in the basic experimental stage. As an emerging treatment strategy, its safety, effectiveness, and feasibility still need further evaluation, and so high-stage clinical trials are urgently needed. In addition, since engineered MSC-exos can obtain different therapeutic characteristics through different engineering methods, their heterogeneity in different patients can result in good targeting adaptability, providing new ideas for the individualized treatment of chronic pulmonary diseases. Although engineered stem cells are an emerging treatment strategy and require further research and clinical trials, their enormous potential does suggest the possibility for conquering difficult-to-treat pulmonary diseases."

If you want to dig into where there might be clinical trials, use this link:
https://clinicaltrials.gov/expert-search
In the search box type [mesenchymal stem cells] space [lungs] (or pulmonary or bronchiectasis) to see what is ongoing, or possibly recruiting. If they are recruiting there will be contact instructions. I cannot vouch for completeness or update on the list - often when a researcher leaves a team, the ball gets dropped and no more info is added.
Those of us who are "research nerds" periodically keep an eye on this and other research, so watch for more info.

Hi Heather, this MAC is a right nuisance. I am going to insist on a 3 x weekly regimen this time as taking the big 3 on a daily basis was tough. I am starting probiotics tomorrow in preparation and will take Ondansetron to help with the nausea - it really helped.
Do you have Bronchiectasis? I hope your Bronch goes well. Let me know how you get on. My next appointment with my ID consultant is on 3rd April. I am more informed this time - I am sure you are too. Good luck. Take care, Niamh

I don't think there is stem cell therapy available for lungs at this time.

Here is what the American Lung Association recently had to say:
https://www.lung.org/lung-health-diseases/wellness/public-health-issues-lung-health/stem-cell-therapy

I am going there November 18. How did you handle all the testing. I took the big 3 for two years resistant to azithromycin. Went off in may starting getting headaches. I think I made a mistake. My Mac has gotten worse. I wish I would have stayed on them or at least stopped the azithromycin but dr did not give me the option 😞

is the am. lung assn. associated with or part of the government=
like ama, fda? there is oversees stem cell that does not have the same regulations as the us. has anyone looked into this?