Can anyone share their experience with Pluvicto?

I was a clinical trial patient for Pluvicto Nov. 2021-May 2022, U. Of Chicago, standard 6 treatment 6 weeks apart. It was a last resort having been through most all standard protocol of surgeries, drugs, radiation, etc. I am stage 4 metastatic castration-resistant. At that time, data showed an typical 11-15 months life extension. My PSA dropped to almost undetectable, PET scans showed many tumors disappeared and others greatly reduced in size. I had a day or two of feeling mildly sick after each treatment, but very, very tolerable. It definitely kicked the can down the road.
Sept. 2024, PSA has shown slight rise and tumors are growing again. Having ruled out other options for one reason or another, many of which I have had, I have started the Pluvicto 6 treatments for the second time, completing the first (#7) three weeks ago. I follow the same post treatment isolation requirements due to the radiation. I had a week of mild upset stomach and annoying headache this time. In three weeks after the 2nd treatment (#8), I"ll have another PET scan to see how the tumors are doing. The PSA has stablized extremely low.
Thus, FOR ME, it saved my life once, so the doctors and I see this as the best option, and I'm doing it again. There is no published data on a patient going through these treatments twice.
Since Pluvicto finds and treats virtually every prostate cancer cell no mater were it is located in the body, I consider it an excellent option for a metastatic patient.

Hi robert, Can pluvicto be infused with a butterfly needle?

Had my 5th Pluvicto thursday and am feeling great. I stopped all other medication which I'm certain was causing all the chaos in my body. After 1 week I was back to normal. No hacking or shortness of breath,no exhaustion no neuropathy, no joint pain, no blurry vision, no confusion. And I sleep great. Now I'll have to wait and see if the Pluvicto has any side affects. I'm not sure what you mean , what were my symtoms? Thank you Gene

I need to correct @jeffmarc's comment. Pluvicto is a targeted therapy that binds to prostate-specific membrane antigen (PSMA), a protein found on prostate cancer cells.
Once bound, the radioactive component of Pluvicto releases radiation that kills the cancer cells, specially lutetium 177Lu, a highly radioactive compound. The treatment delivers gamma radiation that escapes your body and can reach others around you, especially within the first 3 days after each treatment.
I had a full 6 treatments of Pluvicto in 2021-22 as a clinical trial patient for Novartis Pharmaceutical. It was approved in the US shortly afterwards. In mid 2024, my cancer became active, again and I am one a just a handful of patients anywhere in the world repeating the 6 treatment program, completely at my own risk.
I've had numerous targeted beam radiation treatments including the prostate bed and countless PET CT scans and a recent SPECT scan. And, full chemo twice. Yes, lots of radiation. If you have reached the point of receiving Pluvicto, the LEAST of your concerns should be your life radiation accumulation. Yes, too much radiation can effect bone marrow and cause other issues, but those choices might already be out of your necessary, and life saving decision making moving forward. I'm 73, battling cancer for 10 years and so far, I'm doing remarkable well with none of the excessive radiation side effects. Good luck. Don't give up, do what you have to do.

smc24,
I completed my 6th Pluvicto treatment Feb-24 and PSA was .2 until Dec 24 now PSA at 3.
Have contacted my MO for re-treatment of Pluvicto, but not covered by insurance; can you advise me best way to get another 6 treatments.
Best to you

I was one of the original clinical trial patients for what is now, Pluvicto. The pharmaceutical company, Novartis paid for that first round of treatments. I'm 4 of 6 treatments into my "repeat", and Medicare and my supplemental insurer is covering the costs. As you stated and as I learned, Pluvicto is only approved for one set of 6 treatments. So, to answer rayde0's question, I do not know and have not heard of a way to have the repeat round of treatments paid without being a clinical trial patient first.
I hope my experiences and outcome, so far extremely positive, will be a driver for the USFDA's approval of a second round of Pluvicto. But for now, I cannot help you. I know it's easy to say, but stay positive.

76 years old in the same boat your dads in. Treatment #1 not bad at all, treatment #2 a little rough, Treatment #3 a total nightmare, Treatment #5 I didn't think I was going to survive. I don"t have a choice I'll take Treatment #5 and pray..........The rub is , everyone may have a different experience so I suggest gathering more testimonials . Pluvicto with all its unknowns is still the only game in town. If you decide to go through with the treatments you can contact me and I'll share with you some tips on how to make your dads trip easier. God Bless ,Gene

I'm scheduled to begin Pluvicto next week. I've been on ADT for a couple years, cancer has now spread to bones and PSA is up a bit.

Question is: anyone out there receiving Pluvicto ALSO being treated for Pulmonary Fibrosis? I'm taking Ofev for the PF and curious about any interactions or reactions.

thanks