Your comment about clearing the body is very interesting. I've been wondering about this myself. I've noted previously on Mayo Connect comments about Eliquis which I have taken for a few years. Have minimal if any issues with increases in bruising or bleeding. However, my first dose in the AM makes me woozy quite often and for different lengths of time but not the dose in the evening. I've wondered if clearance of the Rx in my system/body or retention times could be a factor in these issues.