1. < COPD: Chronic obstructive pulmonary disease

Misoprostol (Cytotec)

Posted by capnjack @capnjack, 5 days ago

I found a couple of references to the use of misoprostol (prescribed to prevent ulcers and also to induce labor) as a treatment for COPD. A small study in 1995 showed asthmatics using their albuterol inhalers less often, and another study in 2022 showed (in mice) possible actual rebuilding of alveoli! I.e., rebuilding damaged lungs. Anybody else bump into this info?

Interested in more discussions like this? Go to the COPD: Chronic obstructive pulmonary disease Support Group.

ktf | @ktf | 3 days ago
In reply to @jamecline "Misoprostol is already an approved drug with known side effects other drugs are used for crossover..." + (show)
@jamecline

Misoprostol is already an approved drug with known side effects other drugs are used for crossover treatments they weren't originally developed for I'm definitely going to ask my p doc at my next visit

Jump to this post

I’m going to also see what my pulmonologist says
.
The problem is it’s not approved for COPD and insurance will not cover it. Like Dupxient before it was approved for COPD was also not covered by insurance. Nor did my COPD qualify for Dupixent.
But I’ve already printed out the article to bring to my doc on the 12th. Pls let us know what your do. Says jamecline and I’ll do the same.

REPLY
kdalda75 | @kndaustin71 | 1 day ago
In reply to @ktf "Taipan clinical trials often take a long time. Apparently they haven’t moved to human trials yet...." + (show)
@ktf

Taipan clinical trials often take a long time. Apparently they haven’t moved to human trials yet.
For instance I did a clinical trial at Tempke Lung in Philadelphia for my chronic bronchitis - it took almost two years to complete. Luckily I got the actual RheOx treatment for the bronchitis. And my bronchitis is gone. But RheOx has not been approved in the US yet. Once it does get approval it is a game changer for those with the COPD chronic bronchitis!
Tempke Lung is a premier hospital for trials.

Jump to this post

Congratulations. I know their third phase clinical trails have been completed but have not been able to find much info re the results or the status re the FDA. Am a tad put out by mu Pulmo who is the Chief of the Dept. Told me he had nothing else to offer except inhalers I was one...that was enough to get me digging only to find out about the valves/RheOx etc. Unfortunately I had valves placed so was not a candidate for the RheOx study. Further found out that the study was actually being done at the Medical Center that I go to!!!!, as were the valves. Besst have a practicing Pulmo than one in academia!!!!!

REPLY
ktf | @ktf | 1 day ago
In reply to @kndaustin71 "https://copdnewstoday.com/news/gala-therapeutics-pivotal-trial-rheox-system-chronic-bronchitis/#:~:text=The%20U.S.%20Food%20and%20Drug%20Administration%20%28FDA%29%20has,%28COPD%29%20who%20have%20moderate%20to%20severe%20chronic%20bronchitis. Just found this re the RheOx in case anyone is interested." + (show)

Hi kdalda75- thank you for the article.
RheOX for me was definitely a game changer. It’s been well over a year since the treatment & my awesome pulmo tells me “ Your lungs sound great. Even better than my patients that have had the zephyr valves.”
In January she switched my Breztri to Trelegy and I feel really well. She’s very proactive in treatments and we both research to find the latest articles on COPD and discuss them. When I see her on the12th I’ll show her the article on the Misoprostol. Good breathing everyone and God bless you all.

REPLY
1 reply
kdalda75 | @kndaustin71 | 1 day ago
In reply to @ktf "Hi kdalda75- thank you for the article. RheOX for me was definitely a game changer. It’s..." + (show)
@ktf

Hi kdalda75- thank you for the article.
RheOX for me was definitely a game changer. It’s been well over a year since the treatment & my awesome pulmo tells me “ Your lungs sound great. Even better than my patients that have had the zephyr valves.”
In January she switched my Breztri to Trelegy and I feel really well. She’s very proactive in treatments and we both research to find the latest articles on COPD and discuss them. When I see her on the12th I’ll show her the article on the Misoprostol. Good breathing everyone and God bless you all.

Jump to this post

Sounds as though you have a GEM of a physician......I may have to travel. In further review of the literature re RheOx I find that I may not meet the requirement as I have had valves inserted however, under Exclusion one item does refer that acceptance can be made if "lung surgery" was not performed. I contend that the valve insertions are not surgical procedures, but procedures through bronchoscopy...That will illicit some interesting conversation. LOL I have to admit that I am envious that you have such an involve Pulmo. I had to do all the research re treatment options on my own and ended up going to the Research Triangle for valve placement after doing a self-referral. Lucky that I'm in a position to do so. Keep well!

REPLY
ktf | @ktf | 16 hours ago

Evening folks. Something else I’m going to discuss with my pulmo:
Effect of nicotinamide riboside on airway inflammation in COPD: a randomized, placebo-controlled trial
Kristoffer L Norheim et al. Nat Aging. 2024 Dec

REPLY
View MoreView Less
Please sign in or register to post a reply.