I’ve been on HU after being diagnosed with ET as a result of JAK-2 mutation shortly after my 87th birthday. It’s been almost a year and my platelets are dead normal after a dosage of 500mg per day for about 3 months. I’m now only taking HU 4 times a week. I’ve not exhibited any side effects except for a possible increase in Squamous Cell activity. Not sure if it’s related to the HU, as I’ve had issues with skin cancers in the past. Just my days in the sun catching up with me. I was a beach bum in my past life. Having the right Hemo/Onc is a blessing. I’ve got one here in South Florida. Extremely conservative approach to my ET problem, easy to speak with, and compassionate. Live your life to the fullest and don’t worry about your hair. It a small price to pay for a productive life.