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Anyone have intermediate Macular Degeneration

Eye Conditions | Last Active: Feb 24 7:21am | Replies (97)

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@prayingtolucy2

I'm confused. If GA progression on average occurs within 5-8 years And you have double y402h which causes a quick progression to blindness .. You're already 10 years in, intermediate stage, And still have good vision. How's that?

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Replies to "I'm confused. If GA progression on average occurs within 5-8 years And you have double y402h..."

Also, only a small progress to wet. Not everyone progresses to late stage in either wet or dry and it is totally possible to remain stable for many, many years.

I have mountains of drusen ready to flatten and take out my retina and it’s just a matter of time. Maybe because of the longevity drug rapamyacin I have been taking. In 2022 I was seen by so many doctors and I was in pain but now since I have taken rapa for two years I have no old age pain. When they did the AMD and rapa shots study they shot a ton of rapa into an advanced stage GA AMD eye. They found VeG was better. Rapa must be pulsed in low dosages to stop inflammation. My CFH gene mutation means that I cant regulate inflammation. Whereas the ARMS gene mutation means a mitochondria malfunction. Two separate biochemical pathways. Very different mechanisms. Rapa is not an immune suspression drug at a low once a week 5 mg dosage it actually improves it! See Peter Attia’s you tube podcast on it . David Sinclair the Harvard pioneer in disvovery of sirtuins takes a low dose. Rapa only delays progression like AREDS2. Many with double APOE4 gene take rapa to delay progression to dementia. I use a preventive medicine doctor and the cost is 1000 a year for the 2 appts and meds by prescription its a triangular pill from greenstone . “rapamune “. Do not use insurance only good rx. It will not cure the disease only delay progression.

Also found a 2015 areds study which is in conflict with the 3 journal papers articdx emailed me. That must be why genetics isnt tested. The studies are conflicting and all over the place. I’m still taking no zinc AREDS from now on, I think articdx wants to sell you the AMD supplements for your genetics!

https://www.sciencedirect.com/science/article/abs/pii/S0014483521002669
only animal and dead human eyes studies for the elderly what chances I live past 90, my mother and grand mother didn’t . So in my situation it is rational to take it under MD supervision.

Where I got it wrong is not taking HRT after menopause. It is protective. You look younger and feel better. Earlier studies were flawed concerning increase chances cancer? I don’t know. My preventive MD wants me to go on it at 75! Now they talk about how protective it is for your heart. When hormones disappear that’s is the beginning of old age and it’s diseases. My sister with blue eyes 66 is on it and her eyes show no disease. I just didn’t have any menopausal symptoms so I never considered it. .
https://pmc.ncbi.nlm.nih.gov/articles/PMC8949880/

Ok I was corresponding with another person who has no cfh or arms mutations reported by 23 and me but he has intermediate dry and most of the family has AMD . Here’s an exerpt :

“I also downloaded my genome, which indicates that I have the protective variant CFH:rs6677604, which retards the rate of progression. This is an extension of the great good fortune I’ve always been blessed with. “
I don't know how to download the genome (it’s available i think on 23 and me ) to a site which further analyzes protective genes. Could it be even though I have double Y402h I also have protective genes as well? Hmm…