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Jak2 positive, biopsy next: Does it mean I have blood cancer?

Blood Cancers & Disorders | Last Active: Feb 16 9:41am | Replies (35)
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@sbaker343

About 6 months ago a blood test showed very high platelet counts. Next, I tested positive for JAK2 V617F mutation. For a couple of months, I have been taking Hydroxyurea (500 mg) My parameters are basically within limits, but my Dr wants to get the Hematocrit under 45% - last tested at 46.3%. He boosted my Hydroxyurea to 24 x 500mg/week. I get more blood tests next week and will have a tele meeting with my Dr Feb 20. Hoping to reduce medication, while having no negative reactions. I will review the biopsy results in more detail at that meeting.

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Replies to "About 6 months ago a blood test showed very high platelet counts. Next, I tested positive..."
pattycz | @pattycz | Feb 15 7:34am

Best wishes I have the same diagnosis as you as of August 2024 sending you good vibes.

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eileen11108 | @eileen11108 | Feb 15 7:50am

24 Hydroxyurea capsules seems an extreme dose, Hope he is able to lower the dose quickly, Best wishes go out to you.

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stickball1 | @stickball1 | Feb 15 10:01am

Not sure of your stated dosage intake. How many 500 mg (HU) are you taking per day?
I started with one per day and after several weeks my platelet count decreased to 350 from 970. My Hemo/Onc reduced HU to 4 per week and I’m holding my platelet count at 350 for the last 8 months. All other blood values are in spec. No side effects except for an increase of skin lesions (squamous cell carcinoma). I had two removed from my hands last week. Small price to pay in order keep JAK-2 at bay.

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