MTHFR: Anyone else have C677T Polymorphism & allergic to Cobalt?

Hi @lilli64, welcome. I'm tagging a few other members who have MTHFR with the C667T variant, like @ronniekep @msfxit @hodagwi @tamikay @andyinaustin @gldnrtrvrlvr @bet @monk1015 to see if they know if they are allergic to cobalt. You can read more stories in this related discussion:
- Hyperhomocysteinemia with MTHFR C677T mutations. Does anyone have this? https://connect.mayoclinic.org/discussion/hyperhomocysteinemia-with-mthfr-c677t-mutations-does-anyone-have-this/

Lilli, How long have you known that you have this genetic mutation? How did you discover that you're allergic to cobalt?

I found out last year after my GYNO ordered the test I’m not sure what cobalt is

Thank you for connecting my post to other members. I found out last April, when my Therapist was testing me for medications through Genesight, But; I wasn't familure with genetics that much, since then I've been getting sicker and been learning quit a alot. I found out about the Cobalt through patch testing. When trying to figure out why I was having burning mouth syndrome. Unfortunately it is in B12, to my understanding that is what I need to get Methylmalonic acid levels down?. I live in Nebraska not getting alot of help with our broken system here, so trying to figure this out to know what direction I need to take for this.

Hi, Cobalt is a metal that is found in many medicines, foods ect. It is B12 when it comes to Vitamines. Did your Dr. have you take B12 injections for you C677T?

Hi @lilli64, I have MTHFR, with 2 Gene mutations, and am now dangerously allergic to Cobalt. Have you found help?

Hi, @reggraipuf92. While you’re waiting for a response from @lilli64 and their similar experience with your allergic response to Cobalt, I wanted to welcome you to Mayo Connect.
What were your symtoms leading up to the discovery of the mutated genes and your allergy to cobalt?

My MTHFR Mutated genes were discovered 9 years ago after suffering from short-term memory loss and aphasia. I started MTHFR supplements then.
Recently, I started to have a skin reaction to B12. So I took Benadryl. I reduced my intake to a micro dose, for a couple of months. But 22 days ago, I had a full blown reaction with blisters on my arms, and sores in stomach and esophagus. Now My blood work shows my liver is doing poorly. And I have an Excessive amount of Cobalt in my blood, despite not taking it for 22 days.

I have the 2 two mutations also but what do you take that has cobalt? I don't have that but I am extremely sensitive to medication. I was taking gabapentin for neck cervical arthritis and had to stop as it caused low blood pressure and no one could figure it out>My blood work and exam were normal.
However, I had to stop B-12 for awhile as my score was 2000.

Colleen, I apologize for my reply taking so long, it has been a interesting time dealing with the unknown when it comes to health issue's. I happen to hope back online today to print out the info, you had given myself prior for a physcian and seen the steps to took to help in my search ( Im very grateful for) Thank you!

Hi shells14, I also have been taking a type of anticonvulsant for pain, Topamax for Cervical and Neurpathic pain in my lower legs. I wasn't having much luck with getting help back when I originally reach out and spoke with Colleen, I knew I needed to get my methylmalonic acid lowered so on my own I started taking B12 ( Methylcobalmin and Hydroxocobalmin 3000mcg, it definitely brought down my Methylmalonic avid leves after 6 months, But left myself with serious Cystic Acne, along with B12 levels at 3200. As of today, after stopping the B12 supplements my b12 is down to 1500, still dealing with mild Cystic acne, my fatigue is worse than it has ever been, I'm now dealing with Very low Iron, Potassium. Were are you at with everything today, have you found a Physcian that treats Adults?