Tips on minimizing withdrawal symptoms from Effexor (aka Venlafaxine)

Posted by richyrich @richyrich, Nov 2, 2016

I have been taking Effexor/Venlafaxine for years and tried to get off it a few times but each time I try to give up the chemical withdrawal symptoms are a horror story and I give up giving up. Anyone got any tips or tried and tested strategies? Thank you

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@kbmayo

One thing I know loud and clear from my own experience -- and it's not from Effexor, it's from being a sober alcoholic -- is that not eating, which will mean low blood sugar, is a major stressor and contributor to rage/anger/short temper. When I haven't eaten, there's no way my thinking can be even remotely rational. In AA we have a saying ``HALT -- don't get too hungry, angry, lonely or tired'' because we know that any one of those can make it easier to decide to drink again. In fact, I was in a meeting this past week where that was the topic. (Just watch a little kid have a meltdown when she/he is hungry or tired, and you'll see how it works.) I've always had trouble eating because I'm single so I don't have to prepare meals for others and I seldom get really hungry. My psychiatrist told me to eat small but consistently -- string cheese or other decent cheeses, good wheat crackers, sliced turkey, apples or oranges (the fructose is absorbed more slowly). I can't stand Ensure or similar drinks, but I sometimes can motivate myself to make smoothies, which help a lot. My guess -- from my own experience -- is that it's the low blood sugar which is making you question getting off the drug. Your brain is telling you to take the easy way out -- i.e., get back on the dragon.

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You are definitely on the mark about low blood sugar. Fortunately, I can figure out that source of stress with an uptake in fatigue that seems to come with it. It’s odd that one can notice irritability with low blood sugar but explosive anger from withdrawal of Effexor is more like a bolt of lightning on what appears to be an unremarkable day.

Lack of sleep is a major no no too. Unfortunately, Effexor and mental disorders are sensitive and complex interactions that do not like imbalance, don’t tolerate imbalance and start going haywire quickly. If a non -suffering person has brakes made of concrete to stop flash temper and other disturbances, Effexor and imbalance creates one of tinker toys.

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@renwald

Effexor caused that?

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Well that's the thing. I just don't know what is causing what. I am off everything. It was a horrible experience. I couldn't even get myself to the er, I was doubled over with pain.

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@catamite

Well that's the thing. I just don't know what is causing what. I am off everything. It was a horrible experience. I couldn't even get myself to the er, I was doubled over with pain.

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Last I understood, and it still seems to be bitterly true, is that psychiatric medicines are just wildcards.

That is to say,

a) because the brain itself is still largely unknown in all its functions,
B) and because the medicines are largely like a shotgun blast to a whole range of sectors and interactions not understood or even known,

There is no telling what all is actually being affected or the chain reaction/ downstream effects.

I’d say Pharm medicine is a far cry from Thorazine and other jackhammer meds from the past. But, like much of medicine, it’s still a best guess in the most narrow sense with a vast array of unknowns. We are always Guinea pigs.

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@renwald

I have been tapering off for close to a year after taking it for close to ten years. 200mg reduces in quarter tablets over time. I want to be rid of this medicine given I don’t think it helps and if I were to ever have the supply unavailable then the consequences would be bad. I’ve tried cold turkey and it was appalling.

I’ve reviewed many statements about this medicine over the years and do not see a symptom that I assume runs with withdrawal. That symptom is flash rage. It’s the sort of thing that slips effortlessly in your mind and sits around all day waiting for someone to do something wrong. You feel it surge and know what’s happening but too late. You’re willing to stop from walking away and instead go back to just get right up in someone’s face (usually family) and transform from the gentle Dr. Jeckyl to Mr. Hyde. Dr. Jeckyl would not have had to look far to get a better transforming reaction. The change is exceptionally difficult to arrest even when I feel it lurking. It’s rare this pops up but it wouldn’t take much to offend family to the point where they wouldn’t want to be around you anymore. Any ideas on this symptom? I quit following all news of any kind and remove as much provocative stimulation as I can. But withdrawal from people is not really an option.

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I've been completely off for a week now -- and while I wouldn't call my moods "flash rages" - I am very aware of my irritability...particularly in the afternoon to evening. Two suggestions: first - don't do this without some medical supervision. While tapering off Effexor isn't usually dangerous (except to those people who might turn into collateral damage when my moods swing)...it can be very unpleasant....a psychiatrist/psychopharmacologist can help you work through the bumps...sometimes it's just knowing what to expect. Second, it sounds like you may be taking immediate release (not XR) Effexor. It might be worth looking into an extended release formulation....it's a question for the doctor....but it might help a bit.

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@catamite

I understand. I have been effexor free for a weak, and I really shouldn't be around anyone.

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I've been telling my XXBF that for about a month now. Poor guy....but come 4PM - he totally deserves it 🙂

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@youngsally

I've been completely off for a week now -- and while I wouldn't call my moods "flash rages" - I am very aware of my irritability...particularly in the afternoon to evening. Two suggestions: first - don't do this without some medical supervision. While tapering off Effexor isn't usually dangerous (except to those people who might turn into collateral damage when my moods swing)...it can be very unpleasant....a psychiatrist/psychopharmacologist can help you work through the bumps...sometimes it's just knowing what to expect. Second, it sounds like you may be taking immediate release (not XR) Effexor. It might be worth looking into an extended release formulation....it's a question for the doctor....but it might help a bit.

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I’ve been relying on the go but he’s guessing. Eventually I’ll go back to psychiatrist

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@renwald

Last I understood, and it still seems to be bitterly true, is that psychiatric medicines are just wildcards.

That is to say,

a) because the brain itself is still largely unknown in all its functions,
B) and because the medicines are largely like a shotgun blast to a whole range of sectors and interactions not understood or even known,

There is no telling what all is actually being affected or the chain reaction/ downstream effects.

I’d say Pharm medicine is a far cry from Thorazine and other jackhammer meds from the past. But, like much of medicine, it’s still a best guess in the most narrow sense with a vast array of unknowns. We are always Guinea pigs.

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Agree with you 100%. I've done a lot of reading about this since deciding to taper and get free from the Effexor and what I've read about medical trials has been eye-opening (and hair-raising, too!!). If these things weren't such a financial gold mine, they never would have reached this saturation point with patients and doctors. (When I read the new, updated edition of the book about the Sacklers, Purdue and Oxy, I felt like I was reading another version of the same general approach, but one with fatal consequences.)

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@catamite

I feel like I need a time out in a rest home. Someone to feed me, look out for me. I don't know if this was worth it, really. The crying jags are bad, the scary thoughts are worse.

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I am having same side affects!! I lost my mom 4/17 I guess being on these pills made me numb back then, am really feeling the affect of loses my mom now . People think am nuts . Am losing my mind ....

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I’m sorry to hear about your mother. That’s bad enough in its own right let alone with medicines and or underlying conditions. I totally identify with the sedative effect. These meds monkey with the brain so it’s no surprise we would be strangers to ourselves and others. We are losing our minds, the mind that is familiar to us and predictable. Finding a ‘norm’ is really a slippery thing because there is no fair definition but f normal.

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