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Is there anything to help stop or slow progression of MGUS?

Blood Cancers & Disorders | Last Active: 1 day ago | Replies (135)
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@1oldsoul

@hsminc , Thank you for the post. Would you be able to share the link for the article you read? Did it state the participants were on a vegetarian (no meat or dairy) or just a Whole Foods plant based diet? I had previously asked if anyone on the forum had participated in one of Sloan Kettering MGUS clinical trial and had a copy of the allowable foods but I don’t believe anyone responded to the post. Others were interested as well. How long have you been on the plant based diet and do you believe it has had a significant influence on your MGUS markers? I am transitioning to a pescatarian diet- have given up red meat and would have given up all meat except that my digestive system does not handle beans, gluten grains or cows milk dairy so I am concerned about not getting enough protein. Do you feel like you are getting enough protein? I’ll have to find the article I just read and post it, but I believe it said for someone my weight (125) and age (71) that I should be eating 79 grams of protein a day!

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Replies to "@hsminc , Thank you for the post. Would you be able to share the link for..."
hsminc | @hsminc | 4 days ago

I will try to find the link but here is one:
https://pmc.ncbi.nlm.nih.gov/articles/PMC10835229/
It was a preliminary release of data at ASH and referred to the trial that was described on SparkCures.
I have been pretty much a vegetarian all of my life. I do eat dairy, fish and seafood. I eat dairy every day and fish or seafood occasionally - not often.
I don't think I am protein deficient but I don't know. I walk about 3 miles a day and swim. I have energy.
As with causes of MGUS and MM, it is hard to know what has prevented me from developing MM. My dad had SMM *IGA kappa". I have IGG lambda. It started not long after GI surgery for a ruptured appendix. I was horribly sick; had sepsis; would have died except I had a great Mayo surgeon. I was in the hospital close to two weeks with drain tubes getting rid of the pus.
Over the years my FLC have escalated with every joint replacement surgery (4 of them) - all done fabulously well at Mayo. This makes sense in a way because surgery involves inflammation. I had minimal if any pain with any of these surgeries. The pain was before for all of the surgeries but except for the hip, which had disintegrated totally, the FLC did not escalate until after the surgery - and came down a bit but never back to reasonably low. For the hip, my FLC went up before the surgery. Another factor is medications that I take.
I also take ZOCOR and celebrex (brand both of them) and both have been discussed as repurposed drugs for myeloma. There are some VA studies with simivastin and other statin drugs that shows a positive effect on protecting patients from MM and also a study that showed the statin drug affected the myeloma pathway in the liver -- a good thing - mechanism of action is always good to know otherwise you can't really the correlation. My Mayo hematologist did a trial with a Cleveland Clinic hematologist using celebrex. But they could not use reasonably high doses - the dose was minimal. And there were also studies out of California on some celecoxib analogues that looking promising.
I will look for the ASH study later.

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