Strontium citrate (Algaecal) and fractures

Posted by pami @pami, Apr 15, 2024

I am looking to see if there are any studies done that show a reduced chance of fracture from using Strontium citrate (Algaecal) as opposed to calcium. Everything I have read only mentions increase of density using it. Does anyone have doctor input or a study showing an decrease in bone fractures?

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ps @kathleen1314 for some of us the TBS is useless. As you know bone quality is different from density and the connections within bone can be damaged beyond repair. With 7 fractures in my spine, bone quality is obvious.

DEXA is difficult to with L1, L2 and L5 fractures, so I don't realy on that other than comparing from scan to scan.

The REMS interests me (ultrasound) since it is not affected by arthritis or scoliosis but I need to find out the effect of fractures. I plan on asking my doctor about it. Honestly my gains on Tymlos were too good to believe!

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@gravity3

Do you have a strontium that has the most positive research,etc

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strontium citrate has the most positive research, etc.

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@windyshores

ps @kathleen1314 for some of us the TBS is useless. As you know bone quality is different from density and the connections within bone can be damaged beyond repair. With 7 fractures in my spine, bone quality is obvious.

DEXA is difficult to with L1, L2 and L5 fractures, so I don't realy on that other than comparing from scan to scan.

The REMS interests me (ultrasound) since it is not affected by arthritis or scoliosis but I need to find out the effect of fractures. I plan on asking my doctor about it. Honestly my gains on Tymlos were too good to believe!

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I agree the Rems should work better for you according to all the research on REMS.

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@windyshores

But @mcchesney the study that was cited above measured increase in DEXA, which may be a false increase. I would like to see a study on improvement in REMS and TBS if those are now available to more people.

The suggested therapeutic dose for strontium citrate is 680mg, the dose in Strontium Boost.

I am not at all critical of strontium use and tried it 18 years ago for a short time,. I would love good news given my sensitivities to most med options (which I am doing anyway in an adjusted fashion). But I need more than a study showing increase in DEXA on strontium since we know it is denser than calcium and throws the scan results off, I cannot afford to try a year and compare results done the second time with the first- bones can't afford that risk! In any case it may work too slowly for those of us with severe osteoporosis.

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The TBS study showed good bone quality in strontium users with strontium users being in the top 3 in the TBS study.
But yes strontium, unlike most drugs, works with the bodies' own mechanisms to increase bone density and health, so it will not be faster than the body systems or force the body systems or put a stop to any bone turnover in this case. Maybe that is a good thing to be slower than many of the known osteoporosis drugs. Still, I see your point.
We all have to decide what makes us comfortable that is a big part of chosing a bone plan.

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@windyshores

@kathleen1314 not sure you read my post thoroughly. I tried strontium 18 years ago and would consider it after my other treatments, though the cardiovascular effects behind the short term cessation of approval in Europe for the ranelate form did concern me.

More radiologists should adjust the DEXA score for strontium so that improvements can be accurately assessed.

And yes for me it was too slow, but as a follow up to the meds that have helped me so far, I am considering it.

So far, even Keith McCormick , the oft cited author of "The Whole Body Approach to Osteoporosis" and "Great Bones," does not recommend strontium citrate. Clearly more studies are needed. One problem is that it is not a pharmaceutical, ironically, so produces aren't as regulated and ingredients in strontium may not be reliable.

Not sure why you asked if I feel pressured? I chart my own course and have a
"top doc" doctor who is flexible and caring. Osteoporosis meds have time limits and when I am done with low dose Reclast I am taking after Tymlos and 4 months of Evenity, I will need something to keep things going. So far, all my treatment doses have been customized due to various health issues.

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I am sorry if I misread or was less than thorough in my reading of your posting; what did I miss?

Cardio vascular: one population study of older more frail patients showed higher rates of CV Those results have never been able to be reproduced showed CV higher in strontium ranelate patients; Denmark and a couple of other sources tried to reproduce those results, no luck, no CV shown with strontium ranelate. That population study that showed SR with CV elevations is now considered by many a flawed study. Still I would never take strontium ranelate.
If strontium itself caused CV problems then it would seem that anywhere in the world where the ground water has plenty of strontium would have pockets of higher than usual CV problems. That is not the case.

Dexa readings, a now moot issue with REMS and TBS results: But to answer and not ignore your concerns: I personally do not feel the need for a radiologist to adjust my dexa score for strontium any more than they would for any other situation.
The dexa is easily adjusted by about a 10% overread on the first dexa (with a comparison of a no strontium dexa compared to now strontium dexa); then each successive dexa is measured by "is it continuing to get better" beyond 10%.
But frankly, this is a "moot" issue; REMS and TBS both show good bone density and bone quality for strontium users.

Keith McCormick : Why do you use the terminology EVEN Keith McCormick? Is he more likely than other doctors to recommend strontium, in your opinion?

Pressured? I asked "Are you feeling pressured to take strontium?" You seem to think that I meant doctors, ha, I am pretty sure that no USA doctor is pressuring you to take strontium.
Since you are not a strontium user, and you say above that you have a pharma plan mapped out, I was trying to understand where the posts and concerns were coming from about strontium ; I wondered if you felt "pressured" to take strontium by anyone.

I firmly believe that we should all take what makes us feel most comfortable with our decision. For me that is strontium and my now normal bone density plus no fractures or side effects continue to make me comfortable with that decision.

Your bone plan seems well thought out, and you seem comfortable with it. Let us know how it goes; I will celebrate any postitive changes with you.

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@oopsiedaisy

Can you please provide a reference for your claim that most strontium users increase their bone density by more than the 10% adjustment on the DEXA results? Over the years I have considered taking the OTC strontium citrate supplement available in the USA but haven’t been convinced yet of the value especially considering the impact it has on DEXA measurements. I have a 10 year history of measurements on the same machine so I am reluctant to impact that unless there is proven value.

Many thanks.

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The REMS and TBS reports/ self reporting now make the DEXA concerns moot. Both REMS, self reporting and TBS, research show that strontium users have both good density and good bone quality, both in research and in self reporting.
I should have said "many" rather than "most" because no study, research, or self reporting covers most. Pardon the miswording; I usually say many. Plus, the femoral neck always lags behind in any bone meds, even strontium. It is just the nature of the bone.
Here is a study on strontium ranelate users increases:
"In experiments, strontium in bone correlated with strontium in plasma. In this study, strontium ranelate increased bone mineral density at three years by 14.4 percent at the lumbar spine, by 8.3 percent at the femoral neck, and by 9.8 percent at the total hip, and bone strength is directly proportional to bone mineral density"
https://www.nejm.org/doi/full/10.1056/NEJMoa022436
Here is a posting of strontium user stories on Inspire; these are self reports:
https://www.inspire.com/groups/bone-health-and-osteoporosis/discussion/strontium-users-stories-2-alternative-to-pharma-meds/
Are you not doing well on your chosen 10 year bone plan? If you are, I see no reason to change.
I will say that I am not seeing reports of pharma osteoporosis drug users who have, after treatment, had normal bone densities plus, good bone quality. I do see strontium users regularly who self report this.
I have asked several times for osteoporosis drug users to start a posting with good stories about their now normal bone densities and good bone quality, or just good stories. No one has replied or started such a posting. I would love to see one so I may include it in replies to those new posters to osteoporosis boards which ask "what are my options?".

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Below is a posting with a compilation of research and information on Strontium.
Bone biopsies, personal stories, numerous research studies. REMS, DEXA, TBS info and lots of discussion.
https://www.inspire.com/groups/bone-health-and-osteoporosis/discussion/dd823b-strontium-a-compilation-of-research-and-information/

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@kathleen1314

The REMS and TBS reports/ self reporting now make the DEXA concerns moot. Both REMS, self reporting and TBS, research show that strontium users have both good density and good bone quality, both in research and in self reporting.
I should have said "many" rather than "most" because no study, research, or self reporting covers most. Pardon the miswording; I usually say many. Plus, the femoral neck always lags behind in any bone meds, even strontium. It is just the nature of the bone.
Here is a study on strontium ranelate users increases:
"In experiments, strontium in bone correlated with strontium in plasma. In this study, strontium ranelate increased bone mineral density at three years by 14.4 percent at the lumbar spine, by 8.3 percent at the femoral neck, and by 9.8 percent at the total hip, and bone strength is directly proportional to bone mineral density"
https://www.nejm.org/doi/full/10.1056/NEJMoa022436
Here is a posting of strontium user stories on Inspire; these are self reports:
https://www.inspire.com/groups/bone-health-and-osteoporosis/discussion/strontium-users-stories-2-alternative-to-pharma-meds/
Are you not doing well on your chosen 10 year bone plan? If you are, I see no reason to change.
I will say that I am not seeing reports of pharma osteoporosis drug users who have, after treatment, had normal bone densities plus, good bone quality. I do see strontium users regularly who self report this.
I have asked several times for osteoporosis drug users to start a posting with good stories about their now normal bone densities and good bone quality, or just good stories. No one has replied or started such a posting. I would love to see one so I may include it in replies to those new posters to osteoporosis boards which ask "what are my options?".

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Thank you for sharing; I will take a look at these links.

I fractured last year after 5+ years on Fosamax so no, I am not doing well on my bone plan.

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@kathleen1314

The REMS and TBS reports/ self reporting now make the DEXA concerns moot. Both REMS, self reporting and TBS, research show that strontium users have both good density and good bone quality, both in research and in self reporting.
I should have said "many" rather than "most" because no study, research, or self reporting covers most. Pardon the miswording; I usually say many. Plus, the femoral neck always lags behind in any bone meds, even strontium. It is just the nature of the bone.
Here is a study on strontium ranelate users increases:
"In experiments, strontium in bone correlated with strontium in plasma. In this study, strontium ranelate increased bone mineral density at three years by 14.4 percent at the lumbar spine, by 8.3 percent at the femoral neck, and by 9.8 percent at the total hip, and bone strength is directly proportional to bone mineral density"
https://www.nejm.org/doi/full/10.1056/NEJMoa022436
Here is a posting of strontium user stories on Inspire; these are self reports:
https://www.inspire.com/groups/bone-health-and-osteoporosis/discussion/strontium-users-stories-2-alternative-to-pharma-meds/
Are you not doing well on your chosen 10 year bone plan? If you are, I see no reason to change.
I will say that I am not seeing reports of pharma osteoporosis drug users who have, after treatment, had normal bone densities plus, good bone quality. I do see strontium users regularly who self report this.
I have asked several times for osteoporosis drug users to start a posting with good stories about their now normal bone densities and good bone quality, or just good stories. No one has replied or started such a posting. I would love to see one so I may include it in replies to those new posters to osteoporosis boards which ask "what are my options?".

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@kathleen1314 I guess what you missed is that you are kind of preaching to the choir. I used strontium when my bones were mildly osteoporotic. I had cancer and those meds caused severe bone loss and strontium was too slow and gentle for me after all those fractures. I wrote that I am open to considering strontium for maintenance. Not sure why you are writing so much on this to me.

I said "even" because McCormick is a chiropractor known for expertise in holistic approaches who is very open minded and individualizes treatment. His new book is "Great Bones>" I was surprised that he is not on board for strontium.

Last post on this topic for me. It isn't an emotional one for me as it seems to be for you.

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@oopsiedaisy

Thank you for sharing; I will take a look at these links.

I fractured last year after 5+ years on Fosamax so no, I am not doing well on my bone plan.

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There is an Inspire poster that is fairly well known, PhoneyBoney. She was also fracturing on bisphosphonates etc.; I believe that she took various drugs.
She self reports that after taking strontium citrate that she stopped fracturing.
The links which I sent you has a 2020 compilation of strontium research; in that compilation the scientists say that one reason strontium has such a high success of preventing fractures is because it seems to make something called "sacrificial bonds" which allow the bone to sustain more injury.
https://www.inspire.com/groups/bone-health-and-osteoporosis/discussion/dd823b-strontium-a-compilation-of-research-and-information/
I don't know if this sacrificial bond is what stopped PhoneBoney's bisphosphonate fracturing, but it is possible.
Strontium user stories:
https://www.inspire.com/groups/bone-health-and-osteoporosis/discussion/strontium-users-stories-2-alternative-to-pharma-meds/

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