1. < MAC & Bronchiectasis

The wonders of AI in drug discovery!!

Posted by vegita182 @vegita182, 3 days ago

“Mavintramycin A is a new aminohexopyranose nucleoside antibiotic with potent anti-Mycobacterium avium complex (MAC) activity against M. avium and M. intracellulare. Herein, we report the total syntheses of mavintramycin A and its structural analog cytosaminomycin C, which is a known anticoccidial antibiotic. Furthermore, the anti-MAC activities of mavintramycin A, cytosaminomycin C, and their corresponding p-methoxybenzyl-protected analogs were evaluated. Notably, the developed synthetic route enables ready access to various analogs of mavintramycin A for structure-activity relationship studies.”

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Mentor
Sue, Volunteer Mentor | @sueinmn | 2 days ago

@vegita182 And we're waiting - for human studies. So far the studies have involved infected silkworms and mice, which are several iterations from testing in humans.

As always, stay tuned for further information.

PS. When you cite a new drug, treatment or study, it is very helpful to us "research nerds" if you site the source. We try to rely on the sources, and not Meta or AI generated summaries. Thank you.

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1 reply
vegita182 | @vegita182 | 2 days ago
In reply to @sueinmn "@vegita182 And we're waiting - for human studies. So far the studies have involved infected silkworms..." + (show)
@sueinmn

@vegita182 And we're waiting - for human studies. So far the studies have involved infected silkworms and mice, which are several iterations from testing in humans.

As always, stay tuned for further information.

PS. When you cite a new drug, treatment or study, it is very helpful to us "research nerds" if you site the source. We try to rely on the sources, and not Meta or AI generated summaries. Thank you.

Jump to this post

I tried to link the site but it said I couldn’t post phone numbers lol. The filter thought the link was a phone number. This source was science direct.

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2 replies
Mentor
Sue, Volunteer Mentor | @sueinmn | 2 days ago
In reply to @vegita182 "I tried to link the site but it said I couldn’t post phone numbers lol. The..." + (show)
@vegita182

I tried to link the site but it said I couldn’t post phone numbers lol. The filter thought the link was a phone number. This source was science direct.

Jump to this post

Thank you, I'll try to look at it tomorrow.

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Moderator
Colleen Young, Connect Director | @colleenyoung | 2 days ago
In reply to @vegita182 "I tried to link the site but it said I couldn’t post phone numbers lol. The..." + (show)
@vegita182

I tried to link the site but it said I couldn’t post phone numbers lol. The filter thought the link was a phone number. This source was science direct.

Jump to this post

@vegita182, I noticed that you wished to post a link to an article with your posts. You will be able to add URLs to your posts in a few days. There is a brief period where new members can't post links. We do this to deter spammers and keep the community safe. Allow me to post it for you:

- Total syntheses of mavintramycin A and its structural analog, cytosaminomycin C, and evaluation of their antibacterial activities against Mycobacterium avium and Mycobacterium intracellulare https://www.sciencedirect.com/science/article/abs/pii/S0040402024004800

REPLY
1 reply
vegita182 | @vegita182 | 1 day ago
In reply to @colleenyoung "@vegita182, I noticed that you wished to post a link to an article with your posts...." + (show)
@colleenyoung

@vegita182, I noticed that you wished to post a link to an article with your posts. You will be able to add URLs to your posts in a few days. There is a brief period where new members can't post links. We do this to deter spammers and keep the community safe. Allow me to post it for you:

- Total syntheses of mavintramycin A and its structural analog, cytosaminomycin C, and evaluation of their antibacterial activities against Mycobacterium avium and Mycobacterium intracellulare https://www.sciencedirect.com/science/article/abs/pii/S0040402024004800

Jump to this post

Thank you! I’m guessing there is no hope for this drug to be fast tracked?

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