I was prescribed Naltrexone .25 mg, and it's helped so much. I haven't had a full-blown flare up in so long. I can feel when one is coming on, but it never becomes overwhelming where I'm in bed for days at a time. I believe it has lessened the pain but not taken it away completely. I also take 10 mg Baclofen which is a muscle relaxer. Both of these I take at bedtime, they make me sleepy which helps with the sleep issues.