You will be issued with instructions. Follow those. In my two ablations, I was directed to cease taking apixaban the morning before the day of operation (24 hrs) and to stop the metoprolol that evening, so 12 hours prior. The medical team in the cath lab and the intake nurses who prep you will do all that you need, including giving you Plavix or something like it about two hours prior to the operation. You might be asked to take up to five baby aspirins (81 mg of ASA) starting the previous evening, but that was only for a workup angiogram done on me, not on the two ablations....again...read the instructions that you SHOULD receive ahead of the date and follow them.