1. < Pancreatic Cancer

Anyone participate in RMC9805 and RMC6236 clinical trials?

Posted by gnest @gnest, Dec 29, 2024

My mom is fighting pancreatic cancer. She had 12 rounds of FOLFIRINOX, followed by 15 fractions of chemoradiation in a hope to have a Whipple surgery. Unfortunately the surgery was aborted due to discovering liver metastases.
After that she had 3 bi-weekly GemAbrax, bur it didn't work, so her oncologist switch to FOLFIRI with liposomal irinotecan. She had 7 cycles of FOLFIRI. Recently her CA19-9 skyrocketed and her oncologist suggested to enroll in the clinical trail RMC9805 / RMC6236 (targeted KRASG12D) .
If anyone participates in this trail, what is your experience (disease control, side effects, etc.)?
Also, has anyone done histotripsy for liver metastases? If yes, what was your experience?
Thank you

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Moderator
Colleen Young, Connect Director | @colleenyoung | Jan 7 8:35pm

Hi @gnest, your can read more about histotripsy for liver metastases in
- Has anyone out there tried Histotripsy for tumors in the liver?https://connect.mayoclinic.org/discussion/histotripsy-1/
- I recently learned of histotripsy treatment for metastatic NETs https://connect.mayoclinic.org/discussion/i-have-recently-learned-of-a-treatment-for-metastatic-neuroendocrine/

Did your mom decide to take part in the clinical trial?

REPLY
1 reply
mimimmx | @mimimmx | Jan 8 12:08pm

Yes. I am on the RMC trial combo for 6236/9805. I just completed my 4th cycle (every cycle is 3 weeks). I have had an excellent early response with the 1.6cm lesion in my liver and 1.5 cm lesion in my abdomen near my left adrenal gland are too small to measure as of yesterday’s CT scan. My doctor said this is an unusually good response. The side effects are challenging (facial rash that bleeds, scalp sores, mouth sores, diarrhea) but not nearly as difficult as the folfirinox side effects. Doctor has made clear it is not a cure but could extend my life by some time. Let me know if I can answer any other questions.

REPLY
1 reply
gnest | @gnest | Jan 8 7:21pm
In reply to @mimimmx "Yes. I am on the RMC trial combo for 6236/9805. I just completed my 4th cycle..." + (show)
@mimimmx

Yes. I am on the RMC trial combo for 6236/9805. I just completed my 4th cycle (every cycle is 3 weeks). I have had an excellent early response with the 1.6cm lesion in my liver and 1.5 cm lesion in my abdomen near my left adrenal gland are too small to measure as of yesterday’s CT scan. My doctor said this is an unusually good response. The side effects are challenging (facial rash that bleeds, scalp sores, mouth sores, diarrhea) but not nearly as difficult as the folfirinox side effects. Doctor has made clear it is not a cure but could extend my life by some time. Let me know if I can answer any other questions.

Jump to this post

Thank you @mimimmx for your response and sharing your experience. I am glad the treatment works for you. It gives us some hope.
We understand it is not a cure. Hopefully it will be a long-term treatment.
We are waiting for a screening eligibility for this clinical trail.

My mom worries a lot about facial rash. Is there any cream that helps with the rash?

What is nausea situation? Nausea was the main side effect she experienced during prior chemo treatments, so she worries about nausea.

Does it effect your appetite? She barely eat anything now. I worry how the new pills will effect the appetite.

Thanks again

REPLY
1 reply
gnest | @gnest | Jan 8 7:24pm
In reply to @colleenyoung "Hi @gnest, your can read more about histotripsy for liver metastases in - Has anyone out..." + (show)
@colleenyoung

Hi @gnest, your can read more about histotripsy for liver metastases in
- Has anyone out there tried Histotripsy for tumors in the liver?https://connect.mayoclinic.org/discussion/histotripsy-1/
- I recently learned of histotripsy treatment for metastatic NETs https://connect.mayoclinic.org/discussion/i-have-recently-learned-of-a-treatment-for-metastatic-neuroendocrine/

Did your mom decide to take part in the clinical trial?

Jump to this post

Thank you Colleen for providing the information about the histotripsy.

REPLY
mimimmx | @mimimmx | Jan 9 11:48am
In reply to @gnest "Thank you @mimimmx for your response and sharing your experience. I am glad the treatment works..." + (show)
@gnest

Thank you @mimimmx for your response and sharing your experience. I am glad the treatment works for you. It gives us some hope.
We understand it is not a cure. Hopefully it will be a long-term treatment.
We are waiting for a screening eligibility for this clinical trail.

My mom worries a lot about facial rash. Is there any cream that helps with the rash?

What is nausea situation? Nausea was the main side effect she experienced during prior chemo treatments, so she worries about nausea.

Does it effect your appetite? She barely eat anything now. I worry how the new pills will effect the appetite.

Thanks again

Jump to this post

The facial rash is treated proactively with doxycycline and an acne gel applied twice a day. My understanding is that different participants have different levels of severity. Mine was pretty severe to start but after the first two cycles really moderated. Unfortunately, the doxycycline can also be hard on your stomach. My appetite has been modestly suppressed, I eat more frequent, smaller meals. I have only lost a couple pounds since being in the trial. My only nausea has happened when I eat too much too fast. They do prescribe Kytril for nausea. My understanding is that other participants may have had more challenges with nausea. If she is accepted in the trial, there is a Facebook chat group for trial participants that has been helpful to share information. I assume she is KRAS G12D positive. You may want to check out the Facebook Group “KRAS Kickers” and “KRAS G12D Kickers”. Lots of good information being shared across multiple cancer types with the KRAS mutation.

REPLY
1 reply
gnest | @gnest | Jan 9 12:02pm
In reply to @mimimmx "The facial rash is treated proactively with doxycycline and an acne gel applied twice a day...." + (show)
@mimimmx

The facial rash is treated proactively with doxycycline and an acne gel applied twice a day. My understanding is that different participants have different levels of severity. Mine was pretty severe to start but after the first two cycles really moderated. Unfortunately, the doxycycline can also be hard on your stomach. My appetite has been modestly suppressed, I eat more frequent, smaller meals. I have only lost a couple pounds since being in the trial. My only nausea has happened when I eat too much too fast. They do prescribe Kytril for nausea. My understanding is that other participants may have had more challenges with nausea. If she is accepted in the trial, there is a Facebook chat group for trial participants that has been helpful to share information. I assume she is KRAS G12D positive. You may want to check out the Facebook Group “KRAS Kickers” and “KRAS G12D Kickers”. Lots of good information being shared across multiple cancer types with the KRAS mutation.

Jump to this post

Thank you @mimimmx for providing such a detailed information. I will check the Facebook group.

REPLY
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