Does anyone else have MGUS?

Hello,
I've noticed that my urine sometimes is a smidge more bubbly than normal, and sometimes it looks like there's lots of ... little stuff ... floating in it. Not fine enough to call it cloudy but not large either. Has anyone else had this issue? I'm worried about excess protein. My latest round of tests have my FLC amounts and ratio within normal levels but M-Spike popped up slightly to 1.3 from 1.2 six months prior. Currently on an annual testing cycle but the urine has me concerned. No other symptoms, luckily.

Just curious if this is something I should contact my doc about. Thx.

How were you and who diagnosed the chronic Lyme? I’ve been told I may have it, Lyme tests showed some positive tests but my RA DR AND PCP won’t “diagnose” bc they don’t treat it. Found out I have MGUS recently - don’t know what to do with that one either - except yearly tests. I’m interested in getting Lyme diagnosed to see what can be done bc maybe it’ll help with all I have.

I have read that FLCs rise due to infection which makes sense since you had covid. Don’t understand about why lambda would stay elevated but not kappa.
Both kappa and lambda were elevated at my MGUS diagnosis over 3 years ago but now just the lambda remains high. Just within normal range ratio.
I see a MM doc who is monitoring me and thinks it’s nothing to worry about. The M spike isn’t detectable since initial level of 0.2 g/dl in 2021.

FLCs can be high if you have kidney disease but that’s normal for me. And connected to autoimmune diseases.

I think there’s a lot of research currently about FLCs and why they are elevated etc.

Our haemotologist performed bone marrow aspiration and biopsy yesterday.The bone marrow aspiration i have attached hereby.Can you please explain if there is any abnormalities in this you see regarding MM

My.mother's agr is 65.She got M band 0.4 and free light Kappa 100.Our haemotologist told to have bone marrow biopsy and aspiration.Her aspiration reports have arrived.Can anyone please explain what are the results

Hello @karishmagupta, you may notice I removed the image from your post. I did so because it had personal identifying information. Mayo Clinic Connect is a public website and we want to protect our members' identities and personal information.

If you'd like to share images or reports, we recommend blurring out or removing any information that can identify you before posting an image.

Sorry..I have cropped the details .kindly please reply to the image now Iattached hereby.Are there chances of MM?

I have MGUS since 2019. However no one noticed in my blood work until 2024. I suggest u go to a cancer specialist/hematologist if not already. The story from my primary is "oh I have many patients with MGUS" Nothing to worry about. Even from my local cancer center. So I traveled to the Cancer hospital to get a second opinion. And the non cancer MD's stress you do not have cancer. Well I know that but isn't cancer best caught by early diagnosis. My cancer specialist has a very calming but serious recognition of MGUS. so get a second opinion from a Hematologist/oncologist and then decide. I'll stick with the cancer specialist. Occasional check in with the locals if I cant get to the distance if I need for the hematologist oncologist.

I also take the most conservative approach, however at the cancer hospital in my area I opted for the test. The M spike and diagnosis is not a known factor. According to the literature this is an uncommon cancer and my hematologist wanted to know exactly where we were when I went to him. It will allow them to intervene at an appropriate time if they have good benchmarks to start with. In my case the M spike has been in my blood since 2019. I read stories where people never convert, some convert in 5- 7 years etc. Best to take the recommendation of the cancer specialist. Ask for conscious sedation and you won't even fell it. No side effects and gives your oncologist valuable information to treat you specifically.

Definitely see a hematologist/oncologist re MGUS. Local primary may not take it as seriously, and it is interesting that all Myeloma cases are preceded by MGUS, but not all MGUS converts to Multiple Myeloma. About 1% convert or so I have read. So have it checked at least every year if not 6 months. Better safe than sorry. I did see one trial in the literature that is ongoing that is treating MGUS in the country so stay tuned with that. Recommend keeping up with the literature as the cancer breakthroughs change so rapidly it seems to me. NCI has some good literature but if u have a local medical library that is good.