Hi, @squirt0104 - welcome to Mayo Clinic Connect. Sounds like it's been a long road to finally get a diagnosis of aspirin-exacerbated respiratory disease (AERD), or Samter’s Triad. Sounds like you were persistent and observant in getting to that point.

I'd like to point out some reputable information on AERD from the American Academy of Allergy, Asthma & Immunology https://www.aaaai.org/conditions-and-treatments/library/asthma-library/aspirin-exacerbated-respiratory-disease. I'd also like to invite @glj86 @emaria back to this discussion and ask if @lioness @becsbuddy @brightwings might join to provide you some support as you deal with these symptoms and to offer any input they may have. I'm not certain if @imallears @johnbishop are familiar with AERD, but they also may be able to provide some information and/or support.

Feeling like cr&p all the time, even off aspirin, would be very hard. Are there any medications, other treatment or self-care practices that have brought you even temporary relief from your symptoms (tinnitus, weird taste in your mouth, fatigue, confusion, loss of words, headaches, rashes, aches, soreness, rhinitis and sinusitis, etc.), squirt0104?