Hi Mike - I am on Flecainide (100 mg twice a day) and I also take famotidine. I am now taking it every day. In fact, my doctor just suggested taking it twice a day. All of my doctors have a list of my medications, and no one has suggested a conflict. However, after reading the article (thank you for sending, Gloaming) - I will definitely be asking my doctors about this. I have been taking both medicines for 9 months, when I had AF. I have been out of AF since June and am still on the flecainide. I have not had any instances of arrhythmia, and I am well monitored because I have a pacemaker. I would say that the two medications have not cause a problem for me, and I hope they will not cause a problem for you, as well. Betty