Recent diagnosis: Have questions about treatment options?

Posted by mrajat @mrajat, Nov 30, 2024

I am getting diagnosed with pancreatic cancer after an abdominal CT last week. I’m 45 male, South Asian, and married with 8yo twins. I have a healthy lifestyle, run half marathons, and have no family history of cancer among my parents, grandparents or uncles/aunts. I’m still in denial. I started having back pain 1.5 months and abdomen pain 1 month back. The doctor prescribed an abdomen CT scan which found a mass on the pancreatic head 27mm * 24mm. By the time the diagnosis came out, I also developed jaundice (4.9 total bilirubin) although my bilirubin levels have always been elevated (in the range of 1.5 and 3 going back 11 years). They did an ERCP procedure to put in a stent in the bile duct and biopsy the mass. The biopsy results came back inconclusive.
The cancer marker (CA 19-9) measured 153 as of last week. So far, all doctors have said it’s cancer and most likely pancreatic cancer. It seems locally advanced from the CT and MRI. I’m shocked by the grim cure rate / survival rate.
I have seen two surgeons so far. The first surgeon at Univ of Pennsylvania says it’s borderline resectable —so he wants me to get up to 6 months of chemo before attempting surgery / Whipple procedure. The second surgeon at MSK (Memorial Sloan Kettering) ordered a repeat CT scan with focus on pancreas after which he feels comfortable that he can remove it right away and is asking me to go for surgery first.
I have a few questions and would really appreciate your help:
- Could this be anything else?
- Which approach sounds better for overall survival as well as short-term survival: Chemo first then surgery (U Penn) or surgery first (MSK)?
- MSK surgeon has given me surgery appointment for 3 weeks out which is his earliest available. Do you think it’s too risky to wait that long?
Thanks!

Interested in more discussions like this? Go to the Pancreatic Cancer Support Group.

@mrajat

Case Update: I had a whipple procedure at MSK yesterday that was aborted after the surgeon saw cancer cells in the liver upon examining the area and takikg a sample laproscopically. Doctor said it's considered Stage 4 now.
My latest CA19-9 levels (I ordered myself last Sat) were 247, which had gone up in 2 weeks from 176.
I did have jaundice symptoms upon diagnosis a month back and they had put in a stent in the bile duct. I have also had bowel obstruction symptoms for a while now.

I am still in shock and this changes the treatment options entirely. I know there are so many people here who have been battling with stage 4, but I am yet to come to terms with it.

MSK has advised on starting chemo upon getting the path results in a day or two. They said it could be pancreatic or bile duct cancer. They said I should start chemo even before the genetic testing results are out.

I am also considering alternate therapies like Envita in Scottsdale or even some centers in Gemany with wider range of options. Wondering if anyone has used alternative therapies for Stage 4 since the standard course of treatment (chemo, radiation) seem to have poor prognosis.

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mrajat,
Do you have IPMNs in your pancreas?
Read that PC related to IPMN’s has a better prognosis than “regular” PDAC.
Don’t think it changes the treatment options but maybe useful to know.
God bless and good luck.

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@mrajat

Hi Colleen - I decided to go with Adjuvant (surgery first). I am scheduled in about a week. I am also hoping to enroll in a vaccine trial.

Do folks have any recommendation for vaccine trials? I hope I don't get assigned to the "Control" group. Have to figure out how that works.

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@mrajat, thinking of you as you recover from surgery and prepare for your upcoming treatment trial. You might be interested in these related discussions:
- Anyone have experience with mRNA trials for pancreatic cancer?
https://connect.mayoclinic.org/discussion/mrna-trials/
- Pancreatic Cancer Vaccine Therapy (Immunotherapy): What are the facts?
https://connect.mayoclinic.org/discussion/pancreatic-cancer-vaccine/
- Any thoughts on the mRNA vaccine trials for pancreatic cancer?
https://connect.mayoclinic.org/discussion/mrna-vaccine-trials/

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