Patriciaannmelt1 - I would not first look to meds for a consitpation/twisted colon fix. I would look to what you eat and drink. Soft, easy to digest, liquidy foods may help you, along with some natural stool softeners like magnesium. Slipperly elm inner bark powder will add slip. Think hot cereal, smoothies and well-cooked soups. Try avoiding dense food like meat and fish and give bread a break. It can take a lot of experimentation. There are a lot of ideas bantered around here. I really think changing what and how much you eat at a time could be a game changer. It has been for me and I have IBS-C and a severely redundant colon. Some others here do to.