How long after Lupron will testosterone level return to normal?

Posted by komurph @komurph, Feb 14 6:12pm

How long after Lupron therapy will my testosterone return to normal

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@weakbutstrong

Dear Kujhawk1978,
I was an elementary school physical educator who was very interested in the P.E. research concerning cross lateral movements, hamstring and quadracep muscular strength and muscular endurance engagement and the brain pathways and their relationship to reading comprehension. I have never studied the peer reviewed research literature concerning adult males and Testesterone levels and engagement of the Hamstrings and Quadraceps and the possible impact of such aerobic and anerobic exercise upon those Testesterone levels. I must say, I am too old, slow, and worn out to follow this intellectual inquiry, but perhaps one of you gentlemen or your loved one would spend some time looking into the question.
I am happy for you; that you can push your body and enjoy the sights and soumds not only of Nature as you travel through it, but the pulse of your heart as you push it through your exertion levels, the heavy and rapid breathing as you push yourself over steeper terrain and the joy in the accomplishment when completing your physical activity hopefully, daily. You and your experience would suggest that their may be a correlation between long periods of aerobic exercise involving the hamstring and quadracep muscles and an increase in male testesterone for prostate cancer survivors who have used Lupron as a method of ADT (Androgen Deprivation Therapy). Congratulations on your journey to vitality and vigor; I am most happy for you and the hope of possibility it illuminates for many of us. God Bless you all.

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Thanx, this link may help those on this forum in understanding how an active lifestyle contributes to a reduce risk of dying because of PCa - https://www.pcf.org/news/prostate-cancer-loves-couch-potatoes/

For me, it's a blinding flash of the obvious...good to know that some are putting science behind my "intuition..!"

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Sounds like a research grant to me!
Thank you for exploring and posting your knowledge.
That is very interesting
revelation. I will educate more on this matter.

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I received a 6-month injection of Lupron on November 14, 2022. At the 6-month checkup and after 20 sessions of RT my testosterone was 9 and my PSA was < .001. I am a cyclist and before the injection I was riding 150 to 200 miles a week over 4 days with a group. I started slowly feeling the effects of the Lupron about 6 weeks after the injection but keep riding my bike 4 days a week, millage dropped at one point during the RT to 30 miles per week. At my 1-year checkup November 15, 2023, my PSA was still < .001 but my testosterone was up to 488. I am now still riding 4 days a week and 125 miles per week. I feel that I am gaining most of the muscle strength that I lost and am finally being able to put out enough watts on rides to breath hard on the hills, but still struggling on the weight gain from the Lupron. I was able to do a 101-mile ride for my 78th birthday December 15, 2023. I was Gleason 7 4+3 in 3 of 12 cores with a PSA of 7.6 The side effects from the initial injection of Lupron, 15 months later are mostly gone.

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It sounds like to me that you have completely recovered from the ADT but your slow down may be related to gained weight. We are all different I am 15 months post ADT meds etc and my T is 100 and my PSA is .01 I am good with these numbers
Best of luck to you!

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Did either of you experience muscular weakness in your arms and if so is your muscle strength returning to them post ADT and of course loss of libido did it return post ADT???

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I have loss muscle since ADT ( but I am also 77) so a little work around my house and garden results in muscle pain. Tylinol is a big help. My T is 100 15 months after stopping ADT. My primary goal is staying alive and not so much as being athletic.

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Hallo from Italy; I have taken the Lupron for two years; when the cancer was diagnosed my PSA was very high (40) and my general practitioner considered me almost doomed; however the clinical exams was negative about metastasis. The tumor was localized but very big.
Two and a half years after the end of radiotherapy and one year after the discontinuation of Lupron my testosterone is normal at 5,62; my PSA 0,040. I think I was lucky and I thank the Italian public health system that treated me well (Gemelli Hospital Rome).
Best wishes to everyone for their health!

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I received two three monthly injections of Lupron one in May and the other in August this year. This was coupled with 30 sessions of RT from early June to early July. I did a blood test in August and my PSA was at 0.11. I did a second blood test on the 4th of this month. The PSA is now at 0.03. My testosterone level is terribly depressed at 0.6. I have lost a significant amount of muscle strength as a result of which I battle to run a mere two miles. During the RT and after I had been injected with the first dose of Lupron I ran two half marathons. The big T though terribly depressed does not worry me much as my focus is on getting well. I must admit though that I from time to time wonder as to when the T will get to normal levels and the hot flashes will leave me alone.

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