1. < Gynecologic Cancers

Relapse endometrial cancer

Posted by samaco @samaco, Nov 15, 2020

So, I was diagnosed w/stage 1A grade 1 endometrial cancer in May of 2018. After a laparoscopic hysterectomy, all was fine until relapse diagnosed 3 weeks ago. The tumor didn't even show on MRI, and the PET showed nothing. I am about to start radiation. Is there anyone out there in similar situation now or w/past experience? If so, I'd love to hear from you.Thank you.

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Mentor
Helen, Volunteer Mentor | @naturegirl5 | 1 day ago
In reply to @riverland889 "Waiting for notification of appt time with Sloan Kettering, and have virtual next week with Mayo..." + (show)
@riverland889

Waiting for notification of appt time with Sloan Kettering, and have virtual next week with Mayo
For now I’m continuing with Jemperli (immunotherapy)

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@riverland889 Those are both excellent places to get your second and third opinions. Will you let me know what you learn?

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1 reply
val64 | @val64 | 1 day ago
In reply to @angierivas1 "What is a positive signatera test? I haven't heard of it. Thanks. Hope the new treatment..." + (show)
@angierivas1

What is a positive signatera test? I haven't heard of it. Thanks. Hope the new treatment works great for you. 🙏

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Just to elaborate a bit, Signatera tests for tumor DNA in your blood. So it can be used frequently for surveillance.

First, the company sequences the DNA from your tumor surgical specimen, looking for mutations, and then it designs a test just for your tumor that detects those mutations.

My impression from reading the pancreas cancer board is that for them, normal tumor markers start to rise significantly before the Signatera comes up positive. I had a different blood tumor DNA test after my cancer recurrence was clearly visible by CT scan, with several sizable tumors, and it didn't detect anything.

So testing for tumor DNA in your blood is a nice idea, but it seems to have a problem with low sensitivity/false negatives in many cases.

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riverland889 | @riverland889 | 1 day ago
In reply to @naturegirl5 "@riverland889 Those are both excellent places to get your second and third opinions. Will you let..." + (show)
@naturegirl5

@riverland889 Those are both excellent places to get your second and third opinions. Will you let me know what you learn?

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Yes I will

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paz1956 | @paz1956 | 9 hours ago
In reply to @riverland889 "It’s a DNA TEST matched to dna of your tumor" + (show)
@riverland889

It’s a DNA TEST matched to dna of your tumor

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Has anyone had vaginal brachytherapy right after a hysterectomy? If so did you have a reoccurrence? Or you did not have a reoccurrence?I’m 68 stage1a2 not sure if I want/should get the VB treatments. For some reason VB treatments scare me, terribly

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Mentor
Helen, Volunteer Mentor | @naturegirl5 | 22 minutes ago
In reply to @paz1956 "Has anyone had vaginal brachytherapy right after a hysterectomy? If so did you have a reoccurrence?..." + (show)
@paz1956

Has anyone had vaginal brachytherapy right after a hysterectomy? If so did you have a reoccurrence? Or you did not have a reoccurrence?I’m 68 stage1a2 not sure if I want/should get the VB treatments. For some reason VB treatments scare me, terribly

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@paz1956 I looked through your earlier comments and could not figure out if you have already had a hysterectomy? Since you know that you are Stage 1a I'm thinking you have already had a hysterectomy as the stage is assigned in the pathology lab by the pathologist who looks at the tissue that was removed during surgery. What does your oncological surgeon recommend?

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