Kappa light chain is elevated: Anyone dealing with this?

Posted by bettersleep68 @bettersleep68, Aug 28, 2023

Just found out my kappa light chain is elevated....I am worried ....anyone else dealing with this?

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@colleenyoung

@connectingdots, I noticed that you wished to post URLs to several journal articles with your post. You will be able to add URLs to your posts in a few days. There is a brief period where new members can't post links. We do this to deter spammers and keep the community safe.

Allow me to post them for you, including the titles of the papers:
- SARS-CoV-2 Vaccination and Chilblain-like Lesions: What Do We Know so Far? (2022) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681186/
- Free Light Chains κ and λ as New Biomarkers of Selected Diseases (2023) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10253807/

- Post-vaccination COVID Toes (Chilblains) Exacerbated by Rituximab Infusion Suggests Interferon Activation as Mechanism (2021) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8500133/

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Thanks! Those are the ones! I may have one more. I have no idea the quality of the journals, but if other people do, that would be good to know.

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@raye

Hello friends,
First I’ll connect to your discussion then ask a very different question. I have IgM kappa MGUS. My hematologist always likes to see how the kappa is doing and it’s been elevated but fairly stable so far, with normal kappa lambda ratio.

Now for a completely different subject. MGUS was diagnosed in 2015. The following year I had the first experience with a
Migraine Aura without headache. I’ve never had any headache. My question to other MGUS, or related Dx, folks is whether you may have experienced the optical effects of these so-called silent auras. Keeping track, I’ve had about 20 of them since 2016.

I’m posing this question because I’m wondering whether there may be any connection between MGUS and Migraine Aura. Who better to ask than our kind group? Looking forward to hearing from you, as well as any suggestions which may come to mind! Thank you! ~~~Raye

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Hello I have elevated Free Kappa Light Chains (polyclonal so far) and I have had 2 Migraine Aurals happen to me. Very, very scary at first. Were you Polyclonal before the M-spike happened by any chance. But yes, there may be a connection I’m thinking.

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I was wondering how high it is. Mine is elevated too

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@a33

What is a LD4? Where do I find that on the test?

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LD4 is Lactase Dehydrogenase 4 which specifically looks for it in skeletal tissue & liver tissue.

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@fxano

Hello I have elevated Free Kappa Light Chains (polyclonal so far) and I have had 2 Migraine Aurals happen to me. Very, very scary at first. Were you Polyclonal before the M-spike happened by any chance. But yes, there may be a connection I’m thinking.

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I have an elevated Kappa number and a ratio. I also have a slightly elevated m spike. I notice have been having balance problems

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@amyboylan1

I have an elevated Kappa number and a ratio. I also have a slightly elevated m spike. I notice have been having balance problems

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I've had balance problems since December 2023 and I have had every blood test and test done and my kappa was high but they said it was ok ..if it's high it's not ok 😕
My balance dr just said to not show my blood test to my oncologist 😭.
I don't have an oncologist..
But I have inquired at mayo clinic and I will be sending all my paperwork to them
Does this sound familiar 🤔 I'm tired of this and just want to know answers

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Good luck with Mayo. I was denied by them but I know others who got in.

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I was wondering what your Kappa if you’re ok with sharing it.

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@amyboylan1

I have an elevated Kappa number and a ratio. I also have a slightly elevated m spike. I notice have been having balance problems

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I have the same as you. I am having some balance problems too. Not sure if it’s the MGUS or meds I am taking. I am on some new medication.

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@blessedsista24

I've had balance problems since December 2023 and I have had every blood test and test done and my kappa was high but they said it was ok ..if it's high it's not ok 😕
My balance dr just said to not show my blood test to my oncologist 😭.
I don't have an oncologist..
But I have inquired at mayo clinic and I will be sending all my paperwork to them
Does this sound familiar 🤔 I'm tired of this and just want to know answers

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Kappa can be high and not have to be addressed but M spike means you may be progressing from MGUS to worse diagnosis. Keep trying to get seen at Mayo. They do the most bone marrow biopsies do it doesn’t hurt much.

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