Does plant-based eating lower chances of MGUS progressing to myeloma?

I'm 70, and my diet changed 15 years ago, before MGUS (8 years). Because of celiac and collagenous colitis I am gluten free, minimal processed foods, legume free, not meat free but minor part of diet, and no NSAIDs. Risk of progression is about 1% every year, so it stays at asymptomatic MGUS for most people. It is good to have a healthy diet, exercise, control stress, and get enough sleep (the usual recommendations). I do take about a gram of bioavailable curcumin a day (Qunol and Gaia but there are a lot of brands). Bioavailable means the supplement is tied to or modified by lipid (fat) and/or peperine (black pepper) to increase absorption in the GI tract. Turmeric, is good but only contains a few percentage of curcumin and is poorly absorbed. The supplement is used as an antioxidant but can also thin blood so check with a doctor. Here are links that are written to other researchers, so not always easy to understand: https://pmc.ncbi.nlm.nih.gov/articles/PMC7144558/#:~:text=To%20date%2C%20the%20curcumin%20formulation,to%20unformulated%20curcumin%20%5B15%5D.
https://www.researchgate.net/publication/379307195_Regression_of_Intermediate-High_Risk_Monoclonal_Gammopathy_of_Undetermined_Significance_MGUS_With_Long-term_Use_of_Curcumin_A_Case_Report https://pmc.ncbi.nlm.nih.gov/articles/PMC9301229/

I think it’s a very small %that actually turns into MM - I have MGUS to but told not to worry. Eating right and natural will help all sorts of issues.

I as well have mGus and also was told that an extremely small percentage of mGus actually transforms into Multiple Myeloma. I was diagnosed with mGus 20 years ago and was routinely and regularly being followed, tested, and monitored for that long-shot possibility of my mGus transitioning into Multiple Myeloma. However, at one of my regular routine 3-month check-ins with my oncologist on April 5, 2023, I was informed that my mGus had not transitioned into Multiple Myeloma but rather had transformed into an even rarer form of a Non-Hodgkin's Lymphoma similar to Waldenstrom's Macroglobulinemia. My paraproteins had transformed into the even rarer IgG-secreting lymphoplasmacytic lymphoma (LPL) I went through 5 cycles of chemotherapy (Bendamustine and Rituximab) before my 6th cycle was cancelled due to chemo causing very minimal desired results. Chemotherapy had in fact stagnated plateauing at levels considerably below what was anticipated. This led to my treatment changing November 2023 to a BTK Inhibitor called Zanubrutinib which I remain on and will do so for life or until it stops working. I take 4-80mg capsules of Zanubrutinib daily. If I were to miss or stop, all of my symptoms would return much stronger than before. My paraprotrin level, already relatively high, has stopped progressing thanks to Zanubrutinib; however, neither has my paraprotein level dropped or regressed either. Currently, my condition can best be classed as Stable.

Praying for you

I’ve had mgus for about 8 years now. Since January of this year I slowly changed my diet to plant based. Six months after becoming full plant based, my MGUS numbers are stable but the rest of my blood work is now in the normal range. Plant base diet probably isn’t a cure but I do feel a LOT better and have more energy!

That’s great to hear. Any special place you’re finding recipes. Plant based is so new to me

That’s great. Thanks for sharing.

I didn’t find the change that difficult however I do miss cheese! I get recipes on line and bought a Plant based cookbook on Amazon.
I recently started using a free app called Yuka (looks like an orange carrot). You can scan products with this app and it will tell you if it’s good or bad eg. high salt, additives etc.
Good luck

Diagnosed with Waldenstroms disease. Thank you for the information. I confess I know very little about a plant based diet. Your information is encouraging and I will look into it and give it a try.

Nora cooks has gourmet vegan recipes especially good for thanksgiving