Nausea taking 2.4 mg of wegovy. No issues before

Don’t give up. Oh on the nausea my daughter said to try the injection at bedtime and hello no nausea. I’m sorry it’s going slow but try to picture you later. I wish you the best

I start my level 1 (WEGOVY) next Monday. So far very little affect on appetite or snacking. Some minor constipation like symptoms but nothing really than an annoyance.

My PCP stated to start taking Miralax to counter the constipation especially since was starting the 1 next Monday.

Is the consensus that the .25, .50 don't do much? I was told they have to start with low doses to see what side affects you will get thus cannot start with a higher dose. What did you see at the 1 level?

What has been the experience of those taking WEGOVY at the .25, .50, and the 1?

No huge side effects until the last stage of 2.4 mg. On the very first injection I ate a huge breakfast and paid dearly. The last stage has been a tad rough. You can’t slip up one bit or you will feel the nausea and either constipation or diarrhea. Seriously! Makes you eat really well

I'm taking tirzepatide, and yup, nausea and constipation. Gets worse every time I titrate up, so I did increased dosage about half as fast as the clinical trials tested, never got to max dose available, stopped at my goal, and have just started dropping down to find a maintenance dose. In my case, the impacts are clearly dose-dependent.

I'm prone to constipation, and I'll second the 250 mg ducosate recommendation. Also occasional miralax. I've also got a recipe for a home-made product made with dried fruit and senna tea I picked up from a friend with Parkinson's. And I'm largely done with white flour and refined grains, because I need the fiber from groats and whole grain flour.

My primary care physician gave me a nausea prescription for ondansetron, which I use when it is really important to me to not abandon a meal a dozen bites in, such as going out to eat with friends and family. It works quite well. Beyond that, I've got an odd vagus nerve behavior -- I know when to stop trying to power through when I start sneezing. Fortunately, there is negligible delay between triggering food and symptoms, so I've learned pretty quickly which foods are more benign for me than others. (These may not be logical. Most of the time, I can't do soft grain products like bread and pancakes, but I can do toast and crackers. I can do broccoli most of the time, but brussels sprouts only when I'm feeling particularly symptom-free. Trust your own gut.)

I've learned to prioritize protein early in the meal, since these drugs are known for muscle mass impact. I'm also taking a bariatric multi-vitamin.

Apparently some people find that if they switch between GLP-1 RAs, that helps -- they have fewer side effects with some than others. That's my fallback, although I'm not there yet.

Since taking my injection in my thigh and at bedtime no nausea

Good point. I've heard that before -- thigh is slightly less effective, but minimizes side effects. Haven't thought about time of day. I'll have to give that a try.

@srwolfe
I'm really interested in the responses as well. I start my 1.7 WEGOVY next week. No side effects so far and little impact on appetite.

I am reading several posts about injections in thighs. I had not heard this was a better site for side effects. Would this not be closer to muscle mass than stomach? I am hoping my 1.7 starts to decrease appetite and snacking. It has reduced dinner appetite but not snacking afterward.

Am I expecting too much from WEGOVY?