1. < Autoimmune Diseases

Methotrexate and Hydroxychloroquine

Posted by mcc @mcc, Jun 10 7:39pm

I have been trying to taper off Methotrexate but I keep getting flare ups after a couple weeks on the drop so my rheumatologist feels I should add Hydroxychloroquine to the mix for 8-12 weeks then try tapering off the methotrexate again with the goal of being completely off the methotrexate but stay on the hydroxychloroquine. I hate having to be on any medication let alone having to add more to the mix and was wondering if anyone on here has had experience with this and if so , your results? Thank you

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susanjc8 | @susanjc8 | Sep 21 9:03am

I'm always fatigued and brain fogged, but I've never tied it to these meds. I have multiple autoimmune disorders, as well as heart problems, so its sometimes hard to know what is causing what! But I do feel confident that this particular combo has made a world of difference in my overall heath

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livinglife1 | @livinglife1 | Oct 12 2:02pm

I was diagnosed in mid Aug. On methotrexate, one day into 3rd IVIG treatment, hydroxycholorquine….i only have pain right above both knees. Feels more like burning….when the meds start building up in my system does this pain subside at all? Drs says meds take time to build in system. So I feel like it’s a waiting game. Using heating pad to help some as well as Tylenol/ Advil. Thoughts?

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2 replies
mjq | @mjq | Oct 13 5:59am
In reply to @livinglife1 "I was diagnosed in mid Aug. On methotrexate, one day into 3rd IVIG treatment, hydroxycholorquine….i only..." + (show)
@livinglife1

I was diagnosed in mid Aug. On methotrexate, one day into 3rd IVIG treatment, hydroxycholorquine….i only have pain right above both knees. Feels more like burning….when the meds start building up in my system does this pain subside at all? Drs says meds take time to build in system. So I feel like it’s a waiting game. Using heating pad to help some as well as Tylenol/ Advil. Thoughts?

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Please do not take Advil or any product with ibuprofen. Taking methotrexate and nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, ibuprofen, or naproxen together can increase the risk of renal toxicity. Good luck.

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2 replies
reets70 | @reets70 | Oct 13 6:23am

I was on both meds for five years and never had any reactions. I stopped methotrexate 15 years ago and cut down the hydroxy on my rheumatologist advice. I was doing great until PMR hit me with a vengeance last year. Still on hydroxy, and now also prednisone.

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1 reply
livinglife1 | @livinglife1 | Oct 13 5:12pm
In reply to @mjq "Please do not take Advil or any product with ibuprofen. Taking methotrexate and nonsteroidal anti-inflammatory drugs..." + (show)
@mjq

Please do not take Advil or any product with ibuprofen. Taking methotrexate and nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, ibuprofen, or naproxen together can increase the risk of renal toxicity. Good luck.

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Oh goodness. Thank you!

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livinglife1 | @livinglife1 | Oct 14 5:29am
In reply to @reets70 "I was on both meds for five years and never had any reactions. I stopped methotrexate..." + (show)
@reets70

I was on both meds for five years and never had any reactions. I stopped methotrexate 15 years ago and cut down the hydroxy on my rheumatologist advice. I was doing great until PMR hit me with a vengeance last year. Still on hydroxy, and now also prednisone.

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Hoping you get better! Stay strong!

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adlttl123 | @adlttl123 | Oct 14 9:40am
In reply to @mjq "Please do not take Advil or any product with ibuprofen. Taking methotrexate and nonsteroidal anti-inflammatory drugs..." + (show)
@mjq

Please do not take Advil or any product with ibuprofen. Taking methotrexate and nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, ibuprofen, or naproxen together can increase the risk of renal toxicity. Good luck.

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Hello. I understand you feelings about drugs. But let me tell you I went from Xeljanz to RINVOQ and back the last several months and let me tell you that my pain level has never been below a 10. Hydroxychlorquine is the best drug for me. It’s the only drug that helps the congestion in my chest. However you must watch your eye sight. Good luck.

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adlttl123 | @adlttl123 | Oct 14 9:46am
In reply to @livinglife1 "I was diagnosed in mid Aug. On methotrexate, one day into 3rd IVIG treatment, hydroxycholorquine….i only..." + (show)
@livinglife1

I was diagnosed in mid Aug. On methotrexate, one day into 3rd IVIG treatment, hydroxycholorquine….i only have pain right above both knees. Feels more like burning….when the meds start building up in my system does this pain subside at all? Drs says meds take time to build in system. So I feel like it’s a waiting game. Using heating pad to help some as well as Tylenol/ Advil. Thoughts?

Jump to this post

You might like to try ice. Where there’s oain there’s swelling..get the swelling down the pain goes down. On Amazon they are gel filled ice packs flannel covered. Wonderful!! Called Core Products Soft Comfort CorPak. I live by them and have given everyone in my family and all my friends one. God bless!!

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1 reply
livinglife1 | @livinglife1 | Oct 14 3:19pm
In reply to @adlttl123 "You might like to try ice. Where there’s oain there’s swelling..get the swelling down the pain..." + (show)
@adlttl123

You might like to try ice. Where there’s oain there’s swelling..get the swelling down the pain goes down. On Amazon they are gel filled ice packs flannel covered. Wonderful!! Called Core Products Soft Comfort CorPak. I live by them and have given everyone in my family and all my friends one. God bless!!

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Thank you! Getting those now!

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1 reply
adlttl123 | @adlttl123 | Oct 14 7:42pm
In reply to @livinglife1 "Thank you! Getting those now!" + (show)
@livinglife1

Thank you! Getting those now!

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Sorry for the misspelled words. My hands are really in pain right now.

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