I barely notice I have PD when taking Rytary. The off periods were not even noticeable unless I went way late with a dose. Recently, I feel like it’s not helping like it used to. I originally took Sinemet, but it gave me nausea still after several weeks.How long have you gone before you needed to up dosage?I have traveled a lot over the years and I’ve started having problems after returning home from trips. I get nausea, tingling in my fingers and toes, terrible anxiety, vomiting (I know, crazy) loss of appetite and have ended up in ER twice. I’m released after hydration, blood work and usually Ativan to calm me down. I have NEVER gone to ER in my life except when I was in labor. My husband is very worried and says he doesn’t recognize me when we are at the ER. He says he tells doctor and nurses that this absolutely not me.I also started having low blood pressure and was taken off BP meds with no problem. I was diagnosed in 2021 and 72 yrs old. Until recently, I’ve been active, swim a few times a week, ride my 3 wheel trike, participate in lots of family activities, etc.I’m getting paranoid about traveling and afraid I’ll never return to my old self