Yes - I was clear by the second week (February), but stayed on for 5 months just to be sure (doc wanted 6 but I asked to go off at 5 months). I was so tired of the side effects being very, very dry skin. Lips are the worst part, almost unbearable. I have felt two instances of festering of Grover's along a crease across the front of my chest (where I had it before, 5 years). I quickly did cilantro smoothies but just can't seem to stay on them. I do one cilantro pill a day (I thought it might have caused some acne on my chest before). When it festers (can't think of a better way to say it) I have a lot of extra isotretinion pills, so I take one per day for 6 days. It's gone by day three. I can't think of anything I did to bring it on except I've had some health issues and I've been working out very, very hard and running even. Lot's of treadmill but I always do that. I did use a tanning bed a couple few weeks ago. Wondering if that did not help. Gardenjunkie - I find it interesting that you and you sister both have GD. Some sort of genetic thing possibly? I get eczema too - on my lower legs just above ankles. Always same places. Usually in winter - very dry conditions. Triamcinolone usually takes it right away. Now I use a lot of Neutrogena Hydro Boost, especially on the legs - arms.