I just skipped two days of the smoothie because I was away for the weekend at a wedding. Three new little itchy papules showed up. Back on smoothies today! Not sure if it's a lifelong commitment. I will test the waters every month or two. But will be quick to go back if anything new pops up. As for supplements, they don't seem to matter for me. I can go a week or two without them and no difference. I am not a hot tub fan, so can't comment on it. But I do take hot showers again now with no problems.