I have been taking amantadine for long covid brain fog/memory/cognitive issues since April 2024, and like the initial report from 2022, within days people noticed I acted like my old self again. In particular
, I could form and recall memories again, as well think 10x better again, and so do my work well again (I am a scientist, so my brain not working well was a huge problem for the 18 months before).

I convinced my doctor to let me try it based on that nature study for long covid fatigue someone posted above (I also had fatigue) as well as the ongoing clinical trail on using amantadine for long covid cognitive issues.
(Not allowed to post a link, as new here, but it is clinical trial NCT06055244 at Ohio state, if you look at clinical trials for com you should find it with this).

It has also reduced my fatigue, so I can get through a day if needed without a nap. But still feel much better if I can get a nap. But now it can be 20 min instead of the prior required 2h. So easier to incorporate into my day.

I still have POTS from long covid, but that’s decently controlled by Ivabradine and electrolytes.

I have had very few side effects. Main one is I am more sensitive to caffeine since on it, and so I can’t have more than one cup of coffee early in the morning or it makes me jittery and interferes with my sleep. Other one is if I take the prescribed 200 mg, 100 mg in the morning and 100 mg at noon, my sleep is worse. Without much added benefit from taking the second dose over just the morning one that I could notice. So I now only take the 100 mg morning dose and it has been great for me.

Only other thing to note is that one can’t drink alcohol on it. Apparently it greatly amplifies the effect of alcohol and can make you vomit from alcohol. I haven’t tested this. Happy to have my brain back and willing to give up alcohol if that’s the trade I have to make.

Soon my doctor wants me to stop taking it to see if it fixed anything in my brain or if I need it long term. I of course hope it fixed something but also afraid to loose my brain again….guess I’ll find out in the next few weeks.