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Orgovyx extreme fatigue side effects

Prostate Cancer | Last Active: Sep 26 2:04pm | Replies (55)

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@markslice7

Is there anyone in this Prostate Cancer forum that is certain that taking Orgovyx and/or Zytiga has caused muscle stiffness?? I've been taking both drugs since January, 2024, and I now notice that my knees are very stiff which wasn't the case just two months ago. Just curious... Thanks for all the excellent comments thru everyones' experience with your Prostate Cancer journey...

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Replies to "Is there anyone in this Prostate Cancer forum that is certain that taking Orgovyx and/or Zytiga..."

I've been on Zytiga since last december, haven't had any muscle stiffness. Best to all.

Been on Zytiga 17 months, went to two car shows this summer. 1-1 1/2 hour into the car show my legs started tightening up around my knees. Had to leave or sit down immediately. Could be you have a good point about the knees.

I've been getting a lot of leg cramps I attribute to Orgovyx but not general stiffness.

@markslice7, you mention muscle stiffness. I found a couple of related discussions that may help:
- Severe stiffness in fingers after starting Eligard.
https://connect.mayoclinic.org/discussion/severe-stiffness-if-fingers-after-starting-eligard/
- Orgovyx and Zytiga combined
https://connect.mayoclinic.org/discussion/orgovyx-and-zytiga-combined/
Can you describe the muscle stiffness? Is it painful, weak, or just hard to get moving? Is the stiffness in a particular muscle group like legs or fingers? Has it gotten better since you first posted?