Has anyone experienced fatigue after taking losartan for years?

Hello @carolinlv,
I have been taking Losartan for quite some time (5 years) (I am a Kidney transplant recipient). To me ( I am not a Dr) to me it seems your conditions are dose related ( remember Losartan adds potassium to the blood stream) ..so if your Potassium levels are low.. then all kinds to issues surface up such as tingling in the toes/ foot getting stiff or even sometimes the legs feel stiff etc.
If you have such symptoms... make your Dr aware of it.. Can you share why the Dr is using Losartan .. do you have an Adrenal gland issues or excess RBC count. ( In my case it is excess RBC / Hematocrit, issues)
Best

Yes, like the other commenter indicated, talk to your doctor about your symptoms. Otherwise, consider how your Blood Pressure is doing and if the dosage of Losartan could be lowered (only per your doctor's advice!!!). If you can't get in to see your doctor right away, I'd say to take it just before bedtime, not during the day. See if that helps. I've read that there is a factor with Losartan that it may cause drowsiness. I recently changed to taking my Losartan (50 mg) before bedtime and it helps me sleep better. I read about it on-line. Or ask the pharmacist for the product brochure and read that over for common side effects.

If have an ascending aortic aneurysm, but that was never mentioned as a reason to pick a specific blood pressure medication. I started with amlodipine and my feet swelled to the size of a shoebox. They then changed me to losartan. I started out with 100 mg and was a zombie so they dropped me to 50 mg. I do take it at 6 o’clock at night, but I don’t think it’s helping my sleep because my sleep is not good at all. I was also taking 5 mg of bisoprolol with it initially which they dropped to 2.5 and I now don’t take it at all. My BP and heart rate are both under complete control with just the one medication. My blood work was done about six weeks ago and RBC was perfect. I have a cardiologist appointment in two weeks so thank you for the suggested topics to discuss.

I do take it in the evening now. Doesn’t seem to be helping this as my sleep habits are terrible! It really kind of makes no sense to me because I’m sleeping through its peak times. So why am I waking up with zero energy??🤷‍♀️🙇‍♂️

Well, the fact that you have terrible sleep habits is very telling. I can't tell when you are sleeping and whether they are normal sleep periods like most people have or if you have interference like with a job or such. I'm not a doctor, so it seems like you need to start with your Personal Care Physician, see if you can get a referral to an endocrinologist (I'm not a fan of sleep medical offices unless you need to have a CPAP machine or so) and see if you can fit in a nap during the afternoon at all. Something has changed in your sleep schedule or your diet or your daily life schedule. That's what you likely need to work out. I know there are over-the-counter sleep aids like melatonin and Unisom XL (doxylamine succinate) that you could ask your doctor about. Plus do a search in this Mayo Clinic blog for how people improve their sleep regimen and get some hints from there. Good luck, wish I could have more helpful hints for you.

bisoprolol is a beta blocker, In my view all beta blockers cause sleeping issues.( long time back I was using beta blocker) It is good to know that 50mg of losartan is sufficient to control your BP as 50mg of Losartan is good for 8 hours whereas 100mg of Losartan is effective for 24 hours. Another question that comes up: how is your Lipid profile, ask your Dr if you can substitute the Bisoprolol by a Calcium Channel Blocker.
Best Wishes

I took Losartan at a very low dose (12.5 mg per day) for 1 year with no side effects whatsoever but then had to use a different pharmacy because of insurance. The new pharmacy (CVS) filled my Losartan prescription with a pill that looked different and was made by a different company. Just a couple of weeks after starting this new pill I started having some mild fatigue and moderate shortness of breath with a cough. I called my GP and they said that it was unlikely that it was the Losartan. I took myself off of the Losartan (since I am only mildly hypertensive anyway) and all these side effects went away. I made an appointment with my GP and he decided to take me off of the Losartan. He said that all generic drugs have to have the same active ingredient but the filler can be different. He said that I was probably allergic or intolerant to one of the fillers. Has your Losartan pill changed?

my losartan has looked the same for a very long time, but I do know what you’re talking about. The refill I just picked up is an oval shape rather than round. My doctor said the same thing about the inactive ingredients. Thanks for the support! Sometimes I don’t know how crazy my thinking is until I talk to somebody else and hear the same thing!

I’ll dig into the lipid profile. My blood work was just done and doctor was astounded at how good everything looks, but sometimes my questions need to be very direct or I get an overall “you’re doing great!” Thanks for the help!

Pardon me I was never aware that Losartan is dispensed in 12.5mg, I will check it out