Natural high levels of B12 and B6

I had the same problem about a year ago. I started having peripheral neuropathy by my neurologist shortly after getting badly dehydrated. My neurologist did just about every test possible and the only thing that showed up was high vitamin B6 and I was only taking about 25 mg. She told me to stop all B6 immediately. It took a few weeks but I started to get better. About 3 months later I was pretty much back to normal. Apparently many of us (especially those with European ancestry) has a MTHFR gene mutation that causes our body to absorb vitamin B6 (and some other supposedly water soluble vitamins as well) instead of just urinating out the excess. I would suggest stopping not only vitamin B6 supplements but also all fortified foods like cereal and protein powders because many of them contain B6 as well.

It's interesting you said that my mothers maiden name was Johnson and European decent LOL I do know I have a gene where I don't have the enzyme needed to process and absorb B12 wonder if it effects B6 as well.

We may be related!! I have not had that particular test but my son has and he (and I am almost positive me too) have the MTHFR gene mutation which makes our bodies absorb some B vitamins like B6 instead of urinating them out like most water soluble vitamins. I am okay taking B12 and it doesn't bother me but I absolutely cannot take B6 in any supplement. I thought for sure that I had Parkinson's or MS and my neurologist did as well before she found that my B6 was too high. If you know that you have that or a similar gene mutation, I would stay away from all B vitamins until you get a blood test to check your levels. Have a blessed day!

I have taken vitamin B tablets; my vitamin B levels reached low normal. My primary care doctor suggested trying B injections for leg pain. It was a game changer for me. I highly recommend trying it.

Tonyde: Could you tell me specifically what kind of injections you were given? There are many B vitamins.
Thanks!

We may be related!! I have not had that particular test but my son has and he (and I am almost positive me too) have the MTHFR gene mutation which makes our bodies absorb some B vitamins like B6 instead of urinating them out like most water soluble vitamins. I am okay taking B12 and it doesn't bother me but I absolutely cannot take B6 in any supplement. I thought for sure that I had Parkinson's or MS and my neurologist did as well before she found that my B6 was too high. If you know that you have that or a similar gene mutation, I would stay away from all B vitamins until you get a blood test to check your levels. Have a blessed day!

My B6 keeps going High just from food. And monitor my daily intake making sure not to go over the DRA. My doctor won’t test me for the MTHFR mutation. Besides not taking B6 supplement How do you and your son keep your B6 within normal limits? Is there something you take to help? With an extremely strict diet mine my go back to normal range for about a month then right back to being to high again. My doctor is of no help, says everything is fine. My neuropathy says otherwise!