Glaucoma cured in mice!

Wow, that's a positive step. Thanks for sharing!

August 2024 - Here is another study that mentions how Glaucoma was cured in mice by injection of 3 of the Yamanaka Factors with very good safety, yet mice who were genetically engineered to express these factors did not do well. When will human trials start??

"Recent results revealed that the Yamanaka genes display a dual behavior when expressed continuously in vivo, being regenerative when delivered via viral vectors but highly toxic when expressed in transgenic mice. Thus, it has been reported that delivery of the OSK genes by intravitreally injecting a regulatable adeno-associated viral vector type 2 (AAV2) expressing the polycistron OSK can reverse vision deficits in an experimental model of glaucoma in mice as well as in 11 months old mice showing age-related vison impairment. Fifteen months of continuous expression of the OSK genes in retinal ganglion cells (RGCs) induced neither pathological changes nor proliferation of RGCs. Young- and middle-aged mice injected intravenously with OSK-AAV2 for 15 months did not exhibit any adverse side effects. In contrast, DOX-induced expression of OSK genes in mice transgenic for OSK resulted in rapid weight loss and death, likely due to severe dysplasia in the digestive system. "

As a side benefit it was found that the old rats experienced cognitive improvement.
https://link.springer.com/article/10.1007/s11357-024-01269-y

That's a great break through. I wonder how far they are from FDA approval?
I sure hope they come up with a cure for AMD soon as well.

This 2021 review establishes that senescent cells accumulate in the retina and contribute to AMD. (Age-related Macular Degeneration).
(Review) “Cellular senescence in the aging retina and developments of senotherapies for age-related macular degeneration”
https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-021-02088-0
Many companies are working on creating drugs for removal of senescent cells from the body.
One of the problems is finding one that will work on certain types of cells like retinal cells.
Meanwhile just Google "senecent cells" to learn about them. It is possible to reduce some of these cells with a simple, once a month, large 2400 mg dose of Fisetin which is a substance found in small amounts in plants such as strawberries. Because it is not very soluble in water it is best to purchase Liposomal Fisetin. (available at Amazon and others).