Side effects with omeprazole/Prilosec use

Posted by blueorca @blueorca, May 5, 2018

i am an 18-year user of daily OTC Prilosec. It does a perfect job of controlling my GERD but I am constantly battling side effects of nutritional deficiencies in iron, B-12, magnesium, etc. For example, my hair is extremely thin and loss of energy is a constant problem. I am looking for specific help in knowing which supplements to take for this and in what doses and formats and on what schedule. All the nutritionists I've found locally are not well-versed in Prilosec use. Is there a medical provider out there who specializes in this? And would they be willing to work with me long distance?

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Profile picture for drsletmedown @drsletmedown

Short version of a long story. I'm male 71. My Gerd/Reflux started 30 years ago & I was given Prilosec 20mg daily & it worked. I've had EVERY issue I am NOW reading about as side effects & that it was only intended for 14 days ? I've been to Gastros & had colonoscopies & indoscopies as recent as June 2023 & numerous negative stool cultures & ASK for HELP from NUMEROUS Drs over the years to NO avail. I've been hospitalized several times with my diarrhea & low magnesium & NOW to ME it ALL is starting to make SENSE. My biggest concern is I'm muscle wasting & have had testing done & told NO muscle disease. ALL sorts of labs & blood work. CT & MRIs. I'm really getting a lot of loose skin ALL over. I'm weak 40 lbs feel like lifting 100lbs. Aches & pains pretty much everywhere. Hips & knees & shoulders. Have xrayed everything & all I get is you have Osteoarthritis. Offer up MORE pills. I feel like NO one will address it I think since they have continued prescibing it so long & NOW there is so much BAD about it that they are AFRAID to say anything ? My kidney labs are always out of range, borderline anemic & other labs are out of range & when you READ about what they CAN mean a lot lead back to cancer. It's SCARY to THINK this may be related to talking this medication but when I question several years of labs out of range I'm told its OK & expected for my AGE ? Spinal surgeon & Rheumatologist both said Spinal Stenosis in his opinion was causing it & surgery could supposedly stop or slow it but a 6 hr surgery & 3 month recovery sounds scary. ANYONE going through anything like this ? Occular migraines are more & more frequent too does any of THIS sound FAMILIAR to anyone on Omeprazole 20mg. long term? It works but if the drug ruins your quality of life why take it. I tried once to get OFF this & the rebound was awful. I've rotated every other day with Famotidine 20 mg but it falls shot by mid day the next day. Thinking about trying morning & night ? Drs really NO help. I see a lot of lawyers taking cases ? I just want my life BACK & a REAL fix.

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Oh my gosh. I so understand you and found myself nodding in sync with your comments. I live in the Seattle area and have been through thr circuit of G.I. docs, all of whom do not wish to listen and solve my puzzle. It is medicine 2024 and I hate it. It's also medicine post-COVID. I have a dining room table with a large Amazon box on top. Inside the box are 50 or so past Rx's and various other OTC meds. I have an "open house" and invite my friends to take anything. Of course the early birds caught the "best" worms: the opiod based meds, none of which I can tolerate and won't due to my constipation.
I do believe, unfortunately, you are suffering from some degree of Rx overload. It makes sense to me. Have you tried getting into the Mayo Clinic. I personally am waiting to hear from them. Nobody can solve my issue and have severe constipation and bloat. I am 67 and for 65.5 years have been extremely healthy. It sucks!

Best to you.

Beth

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Profile picture for Bonnie @nightngale1998

Hi there: Has anyone had success in weaning off of Omeprazole? I take it for GERD. Thank you in advance!

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I have taken omeprazole on and off for over 20 years. I was treated for helicobacter pylori infection and prescribed omeprazole from then on.
As time has gone on, my GERD symptoms have become progressively worse. Right now, I am in pain almost constantly. I don’t really feel acid coming up in my throat much, but the chest pains and pain in my side are almost unbearable. It affects my life tremendously.
My doctor basically seems to think it’s largely in my head, and he does nothing but prescribe increasing amounts of omeprazole. My current dosage is 40 mg 2x per day. And it does absolutely nothing.
I had been reading about acv and reflux, so I figured why not. I stopped the omeprazole and started 1 tbsp acv in water before each meal. Miraculously, it seemed to work! For a whole week I had the best week in 20 years…then the pain started to return.
I am thinking of dropping the acv…I’ve been on it for 2 weeks now, and also staying off the omeprazole…because it was also not helping. I am at a loss as to what to do though, since I’m in so much pain I don’t even feel like living anymore.
If anyone has suggestions, I’m listening.

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Profile picture for debraj63 @debraj63

I have taken omeprazole on and off for over 20 years. I was treated for helicobacter pylori infection and prescribed omeprazole from then on.
As time has gone on, my GERD symptoms have become progressively worse. Right now, I am in pain almost constantly. I don’t really feel acid coming up in my throat much, but the chest pains and pain in my side are almost unbearable. It affects my life tremendously.
My doctor basically seems to think it’s largely in my head, and he does nothing but prescribe increasing amounts of omeprazole. My current dosage is 40 mg 2x per day. And it does absolutely nothing.
I had been reading about acv and reflux, so I figured why not. I stopped the omeprazole and started 1 tbsp acv in water before each meal. Miraculously, it seemed to work! For a whole week I had the best week in 20 years…then the pain started to return.
I am thinking of dropping the acv…I’ve been on it for 2 weeks now, and also staying off the omeprazole…because it was also not helping. I am at a loss as to what to do though, since I’m in so much pain I don’t even feel like living anymore.
If anyone has suggestions, I’m listening.

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I found a study that shows amla (indian gooseberry) powder is as good as famotidine in handling reflux so I tried this natural solution and haven't taken medication since and its been years.

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Profile picture for Reg @metwo

I found a study that shows amla (indian gooseberry) powder is as good as famotidine in handling reflux so I tried this natural solution and haven't taken medication since and its been years.

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Thanks, but famotodine does absolutely nothing for me either.

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Profile picture for debraj63 @debraj63

Thanks, but famotodine does absolutely nothing for me either.

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Have you had an endoscopy at all during all of this? I was on a PPI and after my 3rd endoscopy, my GI said to never take it again as my digestive tract cells were hypertrophic. If you have had GERD for a long time, have you been tested for SIBO (small intestinal bacteria), a fungal infection, a yeast infection or parasites? All of these can be culprits and need to be treated. A PPI only treats to the symptoms, not the cause of your symptoms. The cause(s) need to be eliminated. Your gut biome can be very unhealthy and needs building back up to deal with any of these infections, in addition using prebiotics and probiotics. This has been my journey and it takes time and the right doctor to test you and knows how to test and treat. Your vitamin and mineral levels also need testing to see what you are deficient in - a poor gut biome is not allowing your digestive tract to take in what is needed for health if your gut cannot digest food you are eating.
Best to you in finding answers.

REPLY
Profile picture for gigi4 @gigi4

Have you had an endoscopy at all during all of this? I was on a PPI and after my 3rd endoscopy, my GI said to never take it again as my digestive tract cells were hypertrophic. If you have had GERD for a long time, have you been tested for SIBO (small intestinal bacteria), a fungal infection, a yeast infection or parasites? All of these can be culprits and need to be treated. A PPI only treats to the symptoms, not the cause of your symptoms. The cause(s) need to be eliminated. Your gut biome can be very unhealthy and needs building back up to deal with any of these infections, in addition using prebiotics and probiotics. This has been my journey and it takes time and the right doctor to test you and knows how to test and treat. Your vitamin and mineral levels also need testing to see what you are deficient in - a poor gut biome is not allowing your digestive tract to take in what is needed for health if your gut cannot digest food you are eating.
Best to you in finding answers.

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Have had several endoscopies, liver scan, gall bladder scan, and no problems with gut biome.
It really IS a mystery.

REPLY
Profile picture for Bonnie @nightngale1998

Hi there: Has anyone had success in weaning off of Omeprazole? I take it for GERD. Thank you in advance!

Jump to this post

REPLY
Profile picture for gigi4 @gigi4

Have you had an endoscopy at all during all of this? I was on a PPI and after my 3rd endoscopy, my GI said to never take it again as my digestive tract cells were hypertrophic. If you have had GERD for a long time, have you been tested for SIBO (small intestinal bacteria), a fungal infection, a yeast infection or parasites? All of these can be culprits and need to be treated. A PPI only treats to the symptoms, not the cause of your symptoms. The cause(s) need to be eliminated. Your gut biome can be very unhealthy and needs building back up to deal with any of these infections, in addition using prebiotics and probiotics. This has been my journey and it takes time and the right doctor to test you and knows how to test and treat. Your vitamin and mineral levels also need testing to see what you are deficient in - a poor gut biome is not allowing your digestive tract to take in what is needed for health if your gut cannot digest food you are eating.
Best to you in finding answers.

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Dr's say improve microbiom with no real details how?
I have fistula down entire esophagus with levels od Barretts so eating healthy does not really work.

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Profile picture for hammock117 @hammock117

Dr's say improve microbiom with no real details how?
I have fistula down entire esophagus with levels od Barretts so eating healthy does not really work.

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There’s an excellent book - Super Gut by Dr. William Davis you can get on Amazon. It’s very helpful.
And eating healthy isn’t an option. Eating healthy is a must to avoid all kinds of health issues.
Get educated about the food in our country and all the additives, preservatives, sugar, chemicals etc that make US food the most unhealthy.
Read ingredients on everything you look at at the grocery store. Know what you’re putting in your body.
As a general rule, avoid sugar, gluten and processed dairy items (go for 100% sheep or goat milk products, grass fed butter, Greek yogurt.)

REPLY
Profile picture for debraj63 @debraj63

I have taken omeprazole on and off for over 20 years. I was treated for helicobacter pylori infection and prescribed omeprazole from then on.
As time has gone on, my GERD symptoms have become progressively worse. Right now, I am in pain almost constantly. I don’t really feel acid coming up in my throat much, but the chest pains and pain in my side are almost unbearable. It affects my life tremendously.
My doctor basically seems to think it’s largely in my head, and he does nothing but prescribe increasing amounts of omeprazole. My current dosage is 40 mg 2x per day. And it does absolutely nothing.
I had been reading about acv and reflux, so I figured why not. I stopped the omeprazole and started 1 tbsp acv in water before each meal. Miraculously, it seemed to work! For a whole week I had the best week in 20 years…then the pain started to return.
I am thinking of dropping the acv…I’ve been on it for 2 weeks now, and also staying off the omeprazole…because it was also not helping. I am at a loss as to what to do though, since I’m in so much pain I don’t even feel like living anymore.
If anyone has suggestions, I’m listening.

Jump to this post

My personal experience is not good either. I’ve been in omeprazole for probably at least 10 years. My Gastrointestinal doc just took me off when it was discovered I have stage 3A kidney disease. So, for me, the question is…did it cause the decline in my kidneys?? I can’t tell you what to do in your situation, but I hope you can get off. I started eating more plant based and that has helped a lot. I still have some bouts of reflux but when I stay strict with eating properly, I’m much better! Best of luck!

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