Testosterone levels are rising after cessation of ADT

Your question raises an interesting question...First, my clinical history (see attached).

After finishing triplet therapy with my last 90 day Lupron shot in May 18, my T rose to 135 by October then 481 by February, eventually 608 in March 2023 when we started back on treatment. After stopping Orgovyx on 3 April after a year, 90 days later T is 328, PSA .001, side effects, gone.

How long will this "vacation" last, who knows but I feel great!

I pondered, well, mused with my medical team, why, if T is the fuel for PCa, did my PCa not "return" until 2022 when it began its rise from .06 to ,77 a year later? The other question we pondered is why my T recovered so rapidly and higher, considerably, than when I started triplet therapy which was 297 when tested at Mayo.

No definitive answer.

As other have said, I'm a layman, no formal medical training, education, or board certifications.

What I do know is the side effects dissipated, hot flashes, fatigue, muscle and joint stiffness and genitalia shrinkage.

So, enjoy, continue to actively monitor your PSA, T and other blood values as appropriate.

Kevin

That is a very good outcome at least for now if you ask me. Your T recovers to levels at which you can rebuild muscle mass which is important to metabolic health.

I'm not a biochemist or similar but my understanding is that long term ADT can cause some cancer cells to perish and others to be damaged or place them into a state of inactivity. How many millions of cancer cells survived your treatment to some degree and are "sleeper cells?" It takes a lot of them to get the PSA meter to budge.

I'm about to enter the first ADT-free phase of my treatment after 2 years of intensified therapy. Trying to figure out everything I can do to improve the ability of my immune system to keep any residual cancer in check in the presence of T. I haven't seen a lot of literature on this particular scenario.