Castration-resistant prostate cancer (CRPC) is defined as:
PSA or cancer progression despite testosterone being kept at castrate levels (usually < 50 ng/dL).
So if your testosterone has climbed back into the normal range, by definition your cancer is not considered castration resistant. It simply means the ADT isn’t suppressing testosterone as intended, or that you’re in an “off-cycle” if you’re on intermittent ADT.
The key thing is that your PSA is still undetectable. That shows your cancer is currently under control. If it were truly castration resistant, we’d expect PSA to start rising while testosterone stayed low.
It would be a good idea to review this with your oncologist:
Double-check your testosterone and PSA with repeat labs.
Clarify whether your treatment plan is continuous or intermittent ADT.
Make sure your medications and dosing are working as intended.
For now, an undetectable PSA is excellent news. The fact that your testosterone is higher doesn’t mean castration resistance — it just means the picture needs a little more clarification with your care team.