Anyone try ketotifen for Long Covid?

Posted by carlosmayo @carlosmayo, Apr 5 11:41am

Has anyone tried ketotifen for Long Covid? And if so did it help, how much do you take, and what if any side effects do you get? Thank you.

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From my own reading, it appears the ketotifen and famotidine (plus the Singulair and Zyrtec I had already been taking) all work against Mast Cell Activitation.

I found this article from the NLM: "Immunological dysfunction and mast cell activation syndrome in long COVID." (I found the article simply by typing "Ketotifen and long Covid.") Check out Table 2 that shows all the symptoms of Mast Cell Activation Syndrome--there are a lot, and I have many of them. The main way to treat them is with antihistamines. See below.

"Usually, MCAS is treated by antihistamines (H1 and H2 blockers), inhibition of synthesis of mediators (zileuton and aspirin), inhibition of mediator release (sodium-cromoglycate), and inhibition of degranulation of mast cells by anti-IgE. Antihistamine, especially H1 receptor blockers, are the cornerstone of the treatment, with a combination of nonsedating (cetirizine, fexofenadine, loratadine, desloratadine, and levocetirizine) and sedating (diphenhydramine, hydroxyzine, cyproheptadine, doxepin, and ketotifen) at doses that could be titrated as indicated up to four times the recommended dose. In addition, a combination with H2 antihistamines (ranitidine, cimetidine, and famotidine) could provide a synergistic histamine receptor blockade and relieve gastrointestinal symptoms [18, 19, 23].

"Inhibition of mediator release by sodium-cromoglycate and, to a lesser extent, ketotifen has been shown to improve skin, gastrointestinal and neuropsychiatric symptoms. As an inhibitor of mediator synthesis, aspirin, montelukast, and zileuton could also provide a synergistic effect. Furthermore, there is no reason to avoid aspirin or other Non Steroidal Anti Inflammatory Drugs once the diagnosis of MCAS has been made if the patient has tolerated these medications previously [18, 19, 24]."

I really should write to the ENT I saw last month when I couldn't get my nose to stop running. I thought I was suddenly allergic to everything in my house. He put me on a steroid nasal spray for 3 weeks; it dried me up, but I could tell it wasn't getting to the root of the problem. (And what a waste of $: he ordered a CT scan of my head and other x-rays.) It wasn't until I started this regimen that I'm starting to feel real relief. I am to take it for 30 days, so I'm halfway through.

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I think I will be done with the Ivermectin today. She only ordered a 14-day dose for me.

I am much better than when I first saw the doctor 2 weeks ago. The headache and dizziness were what I most wanted gone and they are (except for some dizziness that I think is related to my glasses--VERY relieved to find out that there was a mistake with the prescription and they are being remade). But since they have me on quite a cocktail of drugs, it's hard for me to say which in particular did the trick. I can only assume they are all working together.

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