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MGUS FLC Ratio decreasing: Concerned

Blood Cancers & Disorders | Last Active: Jan 12, 2024 | Replies (13)

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Hi,
I am 25M, diagnosed with MGUS at age 22 in Dec 2021. Since then my FLC ratio (IGG Lambda K/L = 0.49) has gone to (K/L = 0.23). My M Protein was 0.4 and now it is 0.8. I am concerned about the steady decrease in the ratio and increase in the M Protein. I have had a BMB as well for baseline measurements, and it showed 3.4% plasma cells. My doctor tells me I am stable, but the trend is worrisome. I have even picked up exercising in the last 1 year, added turmeric (started January 2024), and I am vegeterian. Has anyone's ratio changed or improved? I am looking for insight as my age and MGUS diagnosis worries me a lot.

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Replies to "Hi, I am 25M, diagnosed with MGUS at age 22 in Dec 2021. Since then my..."

@hpatel334
Hi! You are a statistical anomaly with your youth having been diagnosed at such an early age. How did they discover MGUS when you were diagnosed?

@hpatel334
Amazing!
I'm not an expert, but a patient but I believe that my hem/onc doc would be pleased by declining numbers and especially the ratio. Mine were steadily increasing but my last bloodwork showed regression to the lower numbers almost identical to my initial blood work when I was diagnosed three years ago. He didn’t dance, but he did crack a smile which for him is a rare gift.
I find it comforting that progression to multiple myeloma is such a low risk. Beyond that, the advances in treatment over the past decade are remarkable.
The mind/body connection is something that is within my means to control. You are doing all the right stuff with exercise, diet and diligence. Finding that balance that allows us to live life fully and enjoy each day was for me, the next step. My physical self responds when my head is in a good place.
Having said all that, when one gets results that are inconsistent with expectations you do need to ask all the questions. Can you ask your physician to speculate or explain this change? I would be really curious to know as well if you feel comfortable letting me know.

@hpatel334
Watch and wait is a test of our patience. It’s like being surrounded by chaos, but we center ourselves to feel calm in mind and heart. To do otherwise is an exercise in futility. You’ve got this.