Platelets are too high: What can be done to find root cause?

My results were not that quickly. My other blood test have been pretty much ok. Right now I am on 3 a week and platelets are not budging very much. I have had 2 bone marrow biopsies and didn’t show anything. It has been frustrating not having a definitive cause of my high platelets.

Maybe asked already, were you tested for the JAK2 mutation (or others)? This would typically be a blood test (not the BMB). I am not sure I saw that addressed in the string.

I am not sure. When I first went to the hematologist they drew 14 vials of blood. I go back in august I am going to ask my doctor if this was tested for I am sure they did. I think I remember reading about this un some of the result.

Has anyone suggested Anagrelide? I'm not a doctor tho that's what was suggested for me over 20 years ago and still working, no side effects. Check with your oncology hematologist if that might be a solution for you. When I started, it was a new drug under the name Agrylin....it's generic now.

I've been on anagrelide for 40 years with out a problem till this year & now have mylofibrosis & an enlarged spleen! I don't know what I'll be taking now! Going to Mass. General hospital Thursday to talk to a doctor that is experienced in my disease.

I saw the following comment and it may help you understand this condition further :
"
Thrombocythemia and thrombocytosis are conditions that occur when your blood has a higher-than-normal platelet count. Platelets are tiny blood cells. They are made in your bone marrow along with other kinds of blood cells. Platelets are also called thrombocytes, because a blood clot is also called a thrombus.

Thrombocythemia refers to a high platelet count that is not caused by another health condition. This condition is sometimes called primary or essential thrombocythemia.
Thrombocytosis refers to a high platelet count caused by another disease or condition. This condition is often called secondary or reactive thrombocytosis. Thrombocytosis is more common than thrombocythemia.

I saw the following comment and it may help you understand this condition further :
"
Thrombocythemia and thrombocytosis are conditions that occur when your blood has a higher-than-normal platelet count. Platelets are tiny blood cells. They are made in your bone marrow along with other kinds of blood cells. Platelets are also called thrombocytes, because a blood clot is also called a thrombus.

Thrombocythemia refers to a high platelet count that is not caused by another health condition. This condition is sometimes called primary or essential thrombocythemia.
Thrombocytosis refers to a high platelet count caused by another disease or condition. This condition is often called secondary or reactive thrombocytosis. Thrombocytosis is more common than thrombocythemia.

Try an online search for the MPN Research Foundation. Lots of good info. Hopefully you have a heme doc who is familiar with, and perhaps belongs to, this group. You can sign up for their newsletter and learn more. Best wishes!