Both legs sore during day and spasm during sleep. Muscle twitching.

I’m on 7 weeks of the weirdest symptoms. I’ve been to my primary Dr, sports med Dr, Sleep Dr and Neuro-muscular neurologist. None have seen this before. Sleep Dr ruled out RLS. This issue is only when I sleep so it’s not induced by body position. Once I fall asleep, I wake up every 1.5-2.0 hours every night. I haven’t had one night making it 3 straight hours. When I wake up, my upper legs feel tight deep inside the legs and when I straighten them they spasm and the inner cramp releases and I can go right back to sleep. This pattern continues night after night.
I’ve tried everything, epsom salt baths, quinine, thc, CBD, prescription muscle relaxers, warm baths, stretching, foam roller, heat pad, ice, Gabapentin, every sleeping position possible…you name it and I’ve tried it. Has anyone heard of this before and have any suggestions that I can ask the neurologist about on?

I’ve also had sporadic muscle twitching since last March, 2022 but don’t have any muscle weakness. Thank you for any help. My legs are pretty sore throughout the day and if I sit at my office desk for 1/2 hour, when I stand up the hamstrings are so tight and hurt. Neuro thinking most likely a neurological issue but ordered blood tests and a thoracic spine MRI. They feel the brain, lumbar and cevical spine MRI’s look good and do not point to a physical issue being the cause to this. Thank you for any help.