Signatera testing: Has anyone had this done?

2022 and 2023, not 2002

I had a colon cancer mass that was completely blocking my colon, surgically removed in January 2024 -- stage IIA, clear margins, 40 lymph nodes removed, all of which tested negative. I've had no history of any cancer prior to that time. Based in part on my first Signatera evaluation, which came back 0.0, I did not receive chemo or radiation. Reversal surgery for my ostomy bag was done in May, 2024. CT scans done in March, 2024 showed no lesions in any organ in my abdomen. My second Signatera test just came back negative -- 0.0 -- yesterday, June 24, 2024. These test results coincided with my CT scan also done last week, which showed four cancerous tumors in my liver which had not been there in the March CT scan. My oncologist has ordered a biopsy this week. He was rather stunned that this had occurred ... needless to say, so am I.

@mse, you may wish to follow the Colorectal Cancer Support Group here: https://connect.mayoclinic.org/group/colorectal-cancer/

What did you learn from the biopsy? How are you doing?

Diagnosed with stage 3 colon cancer a year ago. Had surgery and 12 rounds of chemo which ended in July. First round of scans and labs looked good however I just received a positive Signatera test. It went from zero to 2.0.
Need a PET scan. Oncologist said not to worry yet but how can I not? Does anyone have experience similar to this? Why would Signatera be positive and it’s not cancer all over again?

I just got my first positive result today. Went from 0 to 0 to .13. My resection (colorectal cancer) was in January of last year, and I did four rounds of CapOx after surgery. I guess that puts us in the same boat, sort of. I’m waiting to hear from my oncology team, as my result came through MyChart and says they haven’t reviewed it yet. Let’s stay in touch, okay?