Anyone Taking Combined Therapy of Tamsulosin + Finasteride for BPH?

Posted by tgregg99 @tgregg99, Apr 15 7:58pm

I'm 72. I've been taking Tamsulosin (Flomax) for a year to treat my BPH (nocturia is my primary symptom), and I've responded well to the med, no issues.

However, because my PSA test results have also inched up above "normal" in recent years (although my free PSA test results were very high, on the good side) my urologist ordered a multipatametric Prostate MRI to see if there were any "areas of concern" (PC lesions). I just got my MRI results, and I have a visit scheduled next month with my urologist to discuss my results and treatment options.

The MRI results show no lesions in the central gland or peripheral zone of the prostate. But the PA said the MRI shows I have an enlarged prostate, so I it confirms what I've been led to believe this past year via my symptoms. I also learned my prostate volume is 97g, which appears very large to me.

Until I talk with my doc, I won't know his next-step recomendation, other than to continue with surveillance. But I'm guessing that he may want to add a 2nd med along with my alpha blocker to see if it could decrease my prostate. I know from our previous talks that he and I are in sync re: conservative treatment and avoiding unnecessary surgery if possible. I'll know soon perhaps what he recommends.

Sorry for my long story here, but I was wondering if anyone is currently taking
an alpha blocker + another med for BPH and if such combo is working to decrease your prostate size.

Thanks so much for your thoughts.

Best wishes!

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@garyinmontara

My experience with the two drugs, tamsulosin and finasteride was mixed. I was on them for about 2 years, ostensibly (I don't know for sure if they worked, but I will assume so per my urologist), to decrease prostate size and open the urethra. They did seem to somewhat help in my overall ability to urinate. However, if I did not urinate when I had the urge (e.g. on a road trip without easy access to a bathroom), I still had painful episodes of not being able to urinate until after several (very minimal, drippy at best) tries. Usually, I could almost empty my bladder after an hour or two. However, they caused a troubling decrease in libido, increased ED, and internal ejaculations 100% of the time. What has caused me the worst problems with not being able to urinate due to BPH since 2010 was having surgery with anesthesia. This began with the first hip replacement in 2010, then 2nd in 2011. After my first shoulder joint replacement in 2020, I began taking the 2 meds; meds were increased after 2nd shoulder joint replacement in 2022...after which I was on a catheter for several days. I had a hernia surgery with anesthesia in February 2024, and could not urinate at all afterwards...had to go to the ER to get catheterized a day after hernia surgery. So, prostate surgery was the only answer. I was on a catheter from February 14 to May 16 2024. Horrible. I had Aquablation surgery on 4/29/24...and the results, for me...have been phenomenal. I wish I had had it sooner. All BPH symptoms are gone...I haven't had such a good urine stream in decades. My libido and ED are much improved, and ejaculations, though nothing like when I was younger (I'm 73) are again all external. Aquablation was wonderful for me.

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Your story is so encouraging, thank you! I would be very fortunate to have such a positive outcome as yours. I'm 72, and have experienced many of the BPH symptoms, medication results, and side effects as you have since I started taking tamsulosin a year ago, and recently, finasteride via combined therapy. I'm pleased with my current state and have tolerated some of the "weird" side effects you mentioned, but so far, nothing unmanageable.

And I just learned I have an inguinal hernia in my scrotum area of my abdomen, after it was found on my MRI, along with my enlarged prostate but with no cancerous lesions. I've had no visible or painful symptoms yet with my hernia, but the general surgeon I met told me what to expect and do if I experience such symptoms.

If and when my time comes to consider minimally invasive procedures for my BPH, I will absolutely discuss the aquablation option with my urologist. Thanks again, and best wishes to you on your return to all things "normal" :-). Enjoy!

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@tgregg99

Your story is so encouraging, thank you! I would be very fortunate to have such a positive outcome as yours. I'm 72, and have experienced many of the BPH symptoms, medication results, and side effects as you have since I started taking tamsulosin a year ago, and recently, finasteride via combined therapy. I'm pleased with my current state and have tolerated some of the "weird" side effects you mentioned, but so far, nothing unmanageable.

And I just learned I have an inguinal hernia in my scrotum area of my abdomen, after it was found on my MRI, along with my enlarged prostate but with no cancerous lesions. I've had no visible or painful symptoms yet with my hernia, but the general surgeon I met told me what to expect and do if I experience such symptoms.

If and when my time comes to consider minimally invasive procedures for my BPH, I will absolutely discuss the aquablation option with my urologist. Thanks again, and best wishes to you on your return to all things "normal" :-). Enjoy!

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Thanks for your response tgregg99! I wish you all the best. I'm probably repeating myself here, but...again, I want to offer caution, based on my experience with BPH: If you have to undergo any surgery that requires anesthesia, beware. BPH was manageable, especially with the meds, until I had any anesthesia. Anesthesia always caused my prostate to shut down completely; several times I needed a catheter for a while after anesthesia. In my most recent case, even though the hernia surgeon and my (former) urologist thought the relatively local anesthesia wouldn't cause a problem, prostate surgery was my only alternative to get rid of the catheter. I was catheterized from the day after the first hernia surgery (2/14/24) until 2 1/2 weeks after aquablation (on 4/29/24), and a week after 2nd hernia surgery (on 5/9/24)...until 5/16/24. That was per the aquablation urologist's recommendation to let the hernia surgery heal somewhat to make sure I'd be able to urinate on my own. Again, best of luck to you!

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When he asked if there was anything else he needed to know prior to a retinal surgery I remember telling my surgeon I am a POUR patient. He said “you’re really not that bad.” I said “thanks, but no - I mean I’m a Post Op Urinary Retention patient. Please put in a catheter before waking me up.” I first discovered I was a POUR patient after a GI surgery, and after this, would always make sure I woke up with a Foley catheter. It could typically be removed a day or two later. I got to the point where I could do it myself.

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@garyinmontara

Thanks for your response tgregg99! I wish you all the best. I'm probably repeating myself here, but...again, I want to offer caution, based on my experience with BPH: If you have to undergo any surgery that requires anesthesia, beware. BPH was manageable, especially with the meds, until I had any anesthesia. Anesthesia always caused my prostate to shut down completely; several times I needed a catheter for a while after anesthesia. In my most recent case, even though the hernia surgeon and my (former) urologist thought the relatively local anesthesia wouldn't cause a problem, prostate surgery was my only alternative to get rid of the catheter. I was catheterized from the day after the first hernia surgery (2/14/24) until 2 1/2 weeks after aquablation (on 4/29/24), and a week after 2nd hernia surgery (on 5/9/24)...until 5/16/24. That was per the aquablation urologist's recommendation to let the hernia surgery heal somewhat to make sure I'd be able to urinate on my own. Again, best of luck to you!

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This is good info, thank you! I've made note and will make sure I discuss potential impacts of anesthesia as needed with my doctor(s).

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