I have been taking imbruvica since August 2020. Started out with 480 mg once a day and I now take 240 mg. I had no symptoms what-so-ever and because of a blood test in 2020 by my PCP it stated my white count was elevated. I am one of the lucky CLL patients as I only have manageable side effects, fatigue is the worse one--so I take a nap. Having a wonderful and caring hematologist also is very reassuring.