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JAK2 Mutation - Effects and Questions
Blood Cancers & Disorders | Last Active: Jun 19 5:59am | Replies (303)Comment receiving replies
i was taking a baby aspirin before the discovery of the jak2 mutation. my platelet count was normal for a long time. When the numbers started to elevate, finally a hematologist checked for this mutation, and sure enough i was positive for the Jak2. I only recently started on hydroxyuria (500mg). The platelet count has remained under 400 with this med. I had stopped taking the baby aspirin when I started the hydroxyuria, but now a new doc is recommending I add it. I'm trying to research whether this addition is necessary. Otherwise, the syndrome is in check. No side effects to report.
Replies to "i was taking a baby aspirin before the discovery of the jak2 mutation. my platelet count..."
Is your new doc an MPN heme specialist? The condition we have is outside the realm of “regular docs”.
I also had PCV dx and was already taking a blood anti coagulant(xarelto) and baby aspirin due to Peripheral Artery Disease. With the JAK2 discovery, hydroxyurea was added. Recently PAD Dr dropped the xarelto, and I stay on baby aspirin and Hydroxy (500g.day), though platelet count is in normal range.
I have been on HX 500mg for last 2 weeks now plus 100mg Aspirin. I have been on Aspirin since Nov. 23 when my platelets were 840. Early this month when Hematologist started me on HX, she insisted i continue taking the Aspirin as well as they both work differently, the aspirin is watching on the clothing part of the equation but HX is reducing the excess production of platelets. My 2 cents!
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I have ET with the JAK2 mutation and my hematologist-oncologist has me on both HU and low-dose aspirin. As he describes it, the HU lowers the platelet count but the platelets that remain are still abnormal and "sticky." The aspirin works with HU to further reduce clotting risks, so it makes sense to take both.