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Prolia and Evenity Together
Today my Endocrinologist recommended I continue taking Prolia, which I have been on for almost 4 years, along with Evenity for one year. I have severe osteoporosis with many fractures through the years. Has anyone else's doctor recommended taking both together?
Thank you.
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Fair enough. Perhaps using the term "rare" is not appropriate here. And I agree that the severity of the events are not captured, but there’s not a lot we can do about that here. I think the MACE events are pretty well defined. Let’s look at the numbers from the package insert (Evenity minus placebo events).
Arthralgia (joint stiffness): 34 in 3,580 = 0.95%
Headache: 27 in 3,580 = 0.75%
Muscle Spasms: 23 in 3,580 = 0.64%
Edema peripheral (swelling from fluid retention): 19 in 3,580 = 0.53%
Asthenia (physical weakness or lack of energy: 5 in 3,580 = 0.14%
Neck Pain: 26 in 3,580 = 0.73%
Insomnia: 4 in 3,589 = 0.11%
Paresthesia (tingling, numbness): 10 in 3,580 = 0.28%
MACE (Major Adverse Cardiac Events)
Myocardial infarction: 1 in 3,580 = 0.03%
Cardiovascular death: 2 in 3,580 = 0.06%
Yes, they are not zero but you should look up the adverse events on Tylenol some time.
From all of the trainings I have attended, all of the doctors will tell you that the reward of the reduced fracture risk outweighs the risk of adverse events (depending on your specific conditions). Now that might not seem true to the people that experience an adverse event, but as a whole, it seems to be true.
I'm all in on informed consent. If I was informed on a recent vaccines adverse events, I never would have taken it. But that’s a whole nother can of worms.
As an engineer, you should be familiar with risk/benefit analyses. I think we all know the benefits but you seem to minimize knowing the risks so we can make the right decision for ourselves.
Also, I seriously doubt any of those taking a placebo ended up in an ER, could not get out of bed for weeks, lost their ability to function for some length of tme, etc . The people on this board who had these experices from one of the medications put "faces" to the numbers. They may be in the minority of users but their experience is real
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2 ReactionsJust about every decision I make includes a risk vs. reward analysis. It drives my wife crazy.
I think you are underestimating the effects of a fracture. How about a 30% 1 year mortality rate after a hip fracture... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428998/ . I have heard numbers closer to 50% based on the age.
We will have to agree to disagree and not highjack rhis thread any longer. Maybe osteoporosis is an overpowering worry for you but I am far more worried about my visit to a neurosurgeon tomorrow. I did not break a bone when falling the other day but may have further damaged my neck.
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2 Reactions#9 means my 9th month . Now I am on my 10th month . 2 more months to go before Reclast .
Kirsti2
How or why did you choose Reclast as a follow up to Evenity?
I consulted 2 endocrinologists and they both re: Reclast….primarily because you can stop reclast if one shot per year works and you might take a holiday for a year and start or not on another year…easier to use…WHERAS if you start with prolia you may end up with reclast anyway…so Reclast sounds more simple ( my translation of their advice)
That is exactly why I wanted Reclast your reasoning exactly and my endocrinologist doesn’t like Prolia and I told her from the start that I would not go on that .